Nonhuman primate models of asthma

被引：52

作者：

Coffman, RL ^{[1
]}

Hessel, EM ^{[1
]}

机构：

[1] Dynavax Technol, Berkeley, CA 94710 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 201卷 / 12期

关键词：

D O I：

10.1084/jem.20050901

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Asthma is a complex human disease that does not have an accurate counterpart in any common model organism. Most of our understanding of the immune mechanisms underlying asthma comes from studies in man and mouse. However, there are fundamental differences between the spontaneous disease in man and the experimentally induced counterparts in mice. We advocate more extensive use of nonhuman primate asthma models to reconcile these differences between man and mouse.

引用

页码：1875 / 1879

页数：5

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