Medical morbidity and mortality in schizophrenia: Guidelines for psychiatrists

被引:231
作者
Goff, DC
Cather, C
Evins, AE
Henderson, DC
Freudenreich, O
Copeland, PM
Bierer, M
Duckworth, K
Sacks, FM
机构
[1] Massachusetts Gen Hosp, Schizophrenia Program, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Endocrinol Program, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Hlth Care Homeless Program, Boston, MA 02114 USA
[4] Massachussets Dept Mental Hlth, Boston, MA USA
[5] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA
[6] Harvard Univ, Sch Med, Boston, MA 02115 USA
关键词
D O I
10.4088/JCP.v66n0205
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background: Medical morbidity and mortality rates remain elevated in schizophrenia patients compared with the general population, in part due to potentially reversible medical risk factors. Psychiatrists should address this problem by adopting established strategies for prevention and intervention. Method: The literature on modifiable medical risk factors relevant to individuals with schizophrenia and corresponding guidelines for prevention and treatment established by expert consensus panels were reviewed. Results: Schizophrenia patients are at elevated risk for cardiovascular disease due to high rates of cigarette smoking and, increasingly, due to obesity, diabetes, and hypertriglyceridemia. Rates of human immunodeficiency virus infection and infectious hepatitis are also higher in schizophrenia patients. Interventions that have reduced medical morbidity in the general population can be adopted to reduce premature mortality in individuals with schizophrenia. Conclusions: Patients with schizophrenia have high rates of potentially reversible medical morbidity. Implementation of practice guidelines for identifying and modifying risk factors could substantially improve the health of patients with schizophrenia.
引用
收藏
页码:183 / 194
页数:12
相关论文
共 127 条
[1]   Group treatment for smoking cessation among persons with schizophrenia [J].
Addington, J .
PSYCHIATRIC SERVICES, 1998, 49 (07) :925-928
[2]   The distribution of body mass index among individuals with and without schizophrenia [J].
Allison, DB ;
Fontaine, KR ;
Heo, M ;
Mentore, JL ;
Cappelleri, JC ;
Chandler, LP ;
Weiden, PJ ;
Cheskin, LJ .
JOURNAL OF CLINICAL PSYCHIATRY, 1999, 60 (04) :215-220
[3]  
Allison DB, 1999, AM J PSYCHIAT, V156, P1686
[4]   The prevalence of hepatitis C virus infection in the United States, 1988 through 1994 [J].
Alter, MJ ;
Kruszon-Moran, D ;
Nainan, OV ;
McQuillan, GM ;
Gao, FX ;
Moyer, LA ;
Kaslow, RA ;
Margolis, HS .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (08) :556-562
[5]  
*AM HEART ASS STEE, 1980, CIRCULATION, V62, pA449
[6]  
American Diabetes Association, 2003, DIABETES CARE S1, V26, pS33, DOI [DOI 10.2337/DIACARE.26.2007.S33, 10.2337/diacare.26.2007.s33]
[7]  
[Anonymous], 2004, J CLIN PSYCHIAT, V65, P267
[8]  
[Anonymous], 1998, Obes Res, V6, p51S
[9]  
[Anonymous], 2003, DIABETES CARE, V26, P51
[10]   A clinical trial of the effects of dietary patterns on blood pressure [J].
Appel, LJ ;
Moore, TJ ;
Obarzanek, E ;
Vollmer, WM ;
Svetkey, LP ;
Sacks, FM ;
Bray, GA ;
Vogt, TM ;
Cutler, JA ;
Windhauser, MM ;
Lin, PH ;
Karanja, N .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (16) :1117-1124