Ischemic renal diseases: New insights into old entities

被引:132
作者
Meyrier, A
Hill, GS
Simon, P
机构
[1] Hop Broussais, Serv Nephrol, F-75674 Paris 14, France
[2] Hop Broussais, INSERM, U430, F-75674 Paris 14, France
[3] Hop Bauchee, Serv Nephrol, St Brieuc, France
关键词
renovasculopathies; nephrosclerosis; hypertension; atherosclerotic renal disease; cholesterol crystal embolism; renal ischemia; renal fibrosis; renin-angiotensin system; angiotensin II; black race; focal segmental glomerulosclerosis; chronic renal insufficiency;
D O I
10.1046/j.1523-1755.1998.00968.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Vascular nephropathies are a steadily increasing cause of end-stage renal failure. Arterio-nephrosclerosis and arteriolonephrosclerosis are common features in the hypertensive patient. This is especially true for blacks of African descent, in whom hypertension and nephrovasculopathies are a major cause of renal insufficiency. That primary hypertension leads to renal vascular lesions, glomerular obsolescence and interstitial fibrosis has long been established. It should not, however, obscure the fact that renal vascular lesions can be observed in animal models as well as in some humans, especially young blacks, in the absence of, or anticipating the onset of hypertension. This leads to considering the hypothesis that nephroangiosclerosis might stem from a genetic defect in the renal vascular bed and that this defect is strongly associated with the hypertensive trait. Atherosclerotic renal disease is a major, potentially treatable cause of chronic renal failure, especially in whites. It leads to renal atrophy, but the ischemic kidney retains a vigorous potential for tubular cell regeneration, which pleads for early recognition and treatment. Recent data suggest that renal ischemia, be it due to renal artery stenosis or to cholesterol crystal embolism, ranks among the multiple causes of secondary focal segmental glomerulosclerosis. Irrespective of its initial mechanism, ischemia induces renal fibrosis, the pathophysiology of which is centered on increased generation of angiotensin II. Finally, renal vascular lesions are commonly observed in the course of various nephropathies, even in the absence of hypertension, and the relationship between these lesions and the unfavorable prognosis of glomerulopathies, especially primary focal-segmental glomerulosclerosis, membranous glomerulopathy and IgA glomerulonephritis, remains to be elucidated. Expanding knowledge of the spectrum of nephrovasculopathies opens perspectives for investigating, understanding and treating a major mechanism of progressive renal insufficiency.
引用
收藏
页码:2 / 13
页数:12
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