Advances in Nod-like receptors (NLR) biology

被引：112

作者：

Barbe, Francois ^{[1
]}

Douglas, Todd ^{[1
]}

Saleh, Maya ^{[1
,2
]}

机构：

[1] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ H3A 2B4, Canada

[2] McGill Univ, Dept Med, Montreal, PQ H3G 0B1, Canada

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2014年 / 25卷 / 06期

关键词：

NLR; Innate immunity; Inflammasome; Inflammation; Cell death; NF-KAPPA-B; INNATE IMMUNE-RESPONSE; REGULATES INFLAMMASOME ACTIVATION; PROMYELOCYTIC LEUKEMIA PROTEIN; TRANSPORTS MURAMYL DIPEPTIDE; GENOME-WIDE ASSOCIATION; LINKS OXIDATIVE STRESS; CLASS-I EXPRESSION; CUTTING EDGE; NALP3; INFLAMMASOME;

D O I：

10.1016/j.cytogfr.2014.07.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The innate immune system is composed of a wide repertoire of conserved pattern recognition receptors (PRRs) able to trigger inflammation and host defense mechanisms in response to endogenous or exogenous pathogenic insults. Among these, nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular sentinels of cytosolic sanctity capable of orchestrating innate immunity and inflammatory responses following the perception of noxious signals within the cell. In this review, we elaborate on recent advances in the signaling mechanisms of NLRs, operating within inflammasomes or through alternative inflammatory pathways, and discuss the spectrum of their effector functions in innate immunity. We describe the progressive characterization of each NLR with associated controversies and cutting edge discoveries. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：681 / 697

页数：17

共 209 条

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