7,7-dimethyl-6,8-dioxabicyclo[3.3.0]oct-3-en-2-one as asynthetic equivalent of ketodicyclopentadiene: a new route to (-)-physostigmine, (-)-physovenine, and (-)-aphanorphine

被引：64

作者：

Tanaka, K ^{[1
]}

Taniguchi, T ^{[1
]}

Ogasawara, K ^{[1
]}

机构：

[1] Tohoku Univ, Inst Pharmaceut, Sendai, Miyagi 9808578, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(00)02171-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new diastercocontrolled route to three alkaloids having a quaternary benzylic stereogenic center, (-)-physostigmine, (-)-physovenine, and (-)-aphanorphine, has been developed using enantiopure 7,7-dimethyl-6,8-dioxabicyclo[3.3.0]oct-3-en-2-one as a synthetic equivalent of chiral cyclopentadienone. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1049 / 1052

页数：4

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