Asymmetric Intermolecular Hydroamination of Unactivated Alkenes with Simple Amines

被引：163

作者：

Reznichenko, Alexander L. ^{[1
]}

Nguyen, Hiep N. ^{[1
]}

Hultzsch, Kai C. ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 47期

基金：

美国国家科学基金会;

关键词：

alkenes; amines; enantioselectivity; intermolecular hydroamination; rare-earth metals; ENANTIOSELECTIVE INTRAMOLECULAR HYDROAMINATION; BASE-CATALYZED HYDROAMINATION; EARTH-METAL CATALYSTS; OLEFIN HYDROAMINATION/CYCLIZATION; KINETIC RESOLUTION; YTTRIUM COMPLEXES; AMIDATE COMPLEXES; C-N; AMINOALKENES; ALKYNES;

D O I：

10.1002/anie.201004570

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A hard nut to crack: The asymmetric intermolecular Markovnikov addition of simple amines to unactivated alkenes can be achieved utilizing binaphtholate rare-earth-metal catalysts with up to 61% ee and 73% de in the case where R 2 contains a stereogenic center. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8984 / 8987

页数：4

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