Antineutrophil cytoplasmic antibodies in autoimmune thyroid disorders

被引：23

作者：

Afeltra, A ^{[1
]}

Paggi, A ^{[1
]}

De Rosa, FG ^{[1
]}

Manfredini, P ^{[1
]}

Addessi, MA ^{[1
]}

Amoroso, A ^{[1
]}

机构：

[1] Univ Rome La Sapienza, Dept Clin Med, I-00185 Rome, Italy

来源：

ENDOCRINE RESEARCH | 1998年 / 24卷 / 02期

关键词：

D O I：

10.1080/07435809809135527

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Different antibodies against both organ- and non-organ-specific autoantigens have been found in patients with autoimmune thyroid diseases. he aim of our study was to evaluate the presence of antineutrophil cytoplasmic antibodies (ANCA) in sera of patients affected by Graves' disease (GD) and Hashimoto's thyroiditis (HT). These antibodies were investigated by indirect immunofluorescence; the reactivity against myeloperoxidase and lactoferrin was assessed by ELISA. ANCA were detected by immunofluorescence in 28.5% of patients with GD and 9% of patients with HT. Anti-lactoferrin antibodies were found in 3 of 21 (14.2%) patients affected by GD and in 2 of 11 (18.1%) cases of HT. Anti-myeloperoxidase antibodies were detected only in one (4.7%) patient with GD.

引用

页码：185 / 194

页数：10

共 20 条

[1] CD5 B cells in autoimmune and non immune-mediated thyroid dysfunctions. [J].

Afeltra, A ;

Ferri, GM ;

Amoroso, A ;

Leri, O ;

Pellegrino, C ;

Guido, F ;

Garzia, P ;

Paggi, A .

ENDOCRINE RESEARCH, 1997, 23 (1-2) :81-94

[2]

Afeltra A, 1996, J RHEUMATOL, V23, P10

[3] CD5+ B-LYMPHOCYTES AND CD4+CD45RA+ T-CELLS IN GRAVES-DISEASE [J].

AFELTRA, A ;

PAGGI, A ;

FERRI, GM ;

AMOROSO, A ;

DIPRIMA, MA ;

STARTARI, S ;

FARALLI, AR ;

BONOMO, L .

ENDOCRINE RESEARCH, 1993, 19 (01) :73-85

[4]

ARDEMAN S, 1966, Q J MED, V35, P421

[5] ANTIBODIES TO NUCLEAR ANTIGENS IN GRAVES-DISEASE [J].

BAETHGE, BA ;

LEVINE, SN ;

WOLF, RE .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1988, 66 (03) :485-488

[6]

CALDAS ML, 1991, AM J KIDNEY DIS, V18, P204

[7] ANTILACTOFERRIN ANTIBODIES IN PATIENTS WITH RHEUMATOID-ARTHRITIS ARE ASSOCIATED WITH VASCULITIS [J].

COREMANS, IEM ;

HAGEN, EC ;

DAHA, MR ;

VANDERWOUDE, FJ ;

VANDERVOORT, EAM ;

KLEIJBURGVANDERKEUR, C ;

BREEDVELD, FC .

ARTHRITIS AND RHEUMATISM, 1992, 35 (12) :1466-1475

[8] AUTOIMMUNITY IN PERNICIOUS ANEMIA AND THYROIDITIS - A FAMILY STUDY [J].

DONIACH, D ;

ROITT, IM ;

TAYLOR, KB .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1965, 124 :605-&

[9]

DONIACH D, 1963, BRIT MED J, V5342, P134

[10] ANTI-NEUTROPHIL CYTOPLASMIC AUTOANTIBODIES WITH SPECIFICITY FOR MYELOPEROXIDASE IN PATIENTS WITH SYSTEMIC VASCULITIS AND IDIOPATHIC NECROTIZING AND CRESCENTIC GLOMERULONEPHRITIS [J].

FALK, RJ ;

JENNETTE, JC .

NEW ENGLAND JOURNAL OF MEDICINE, 1988, 318 (25) :1651-1657

← 1 2 →