Donepezil-induced REM sleep augmentation enhances memory performance in elderly, healthy persons

被引：71

作者：

Schredl, M ^{[1
]}

Weber, B ^{[1
]}

Leins, ML ^{[1
]}

Heuser, I ^{[1
]}

机构：

[1] Cent Inst Mental Hlth, Sleep Lab, D-68072 Mannheim, Germany

来源：

EXPERIMENTAL GERONTOLOGY | 2001年 / 36卷 / 02期

关键词：

donepezil; REM sleep; memory; elderly;

D O I：

10.1016/S0531-5565(00)00206-0

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Previous research in younger individuals has shown that acetylcholinesterase inhibitors may enhance REM sleep. The present study indicates that in the elderly, donepezil, an acetylcholinesterase inhibitor, also exerts a marked effect on REM sleep parameters - percentage of REM sleep and REM density were increased whereas REM latency was reduced. In addition, we also found a correlation between memory performance and REM sleep. Based on these findings, we conclude that there is an interrelationship between cognitive performance and amount of REM sleep in elderly humans as has been previously shown in animals and young adults. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：353 / 361

页数：9

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