Prevalence of and Risk Factors for Human Papillomavirus (HPV) Infection Among HIV-Seronegative Men Who Have Sex With Men

被引：143

作者：

Goldstone, Stephen ^{[1
]}

Palefsky, Joel M. ^{[2
]}

Giuliano, Anna R. ^{[3
]}

Moreira, Edson D., Jr.

Aranda, Carlos

Jessen, Heiko ^{[4
]}

Hillman, Richard J. ^{[5
]}

Ferris, Daron G. ^{[6
]}

Coutlee, Francois ^{[7
]}

Liaw, Kai-Li ^{[8
]}

Marshall, J. Brooke ^{[8
]}

Zhang, Xuehong ^{[9
]}

Vuocolo, Scott ^{[8
]}

Barr, Eliav ^{[8
]}

Haupt, Richard M. ^{[8
]}

Guris, Dalya ^{[8
]}

Garner, Elizabeth I. O. ^{[8
]}

机构：

[1] Mt Sinai Sch Med, New York, NY 10011 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[3] H Lee Moffitt Canc Ctr & Res Inst, Risk Assessment Detect & Intervent Program, Tampa, FL USA

[4] J2 Private Clin Infect Dis, Berlin, Germany

[5] Univ Sydney, STI Res Ctr, Sydney, NSW 2006, Australia

[6] Med Coll Georgia, Gynecol Canc Prevent Ctr, Augusta, GA 30912 USA

[7] Univ Montreal, CHUM, Ctr Rech, Montreal, PQ, Canada

[8] Merck, N Wales, PA USA

[9] Harvard Univ, Sch Publ Hlth, Dept Epidemiol & Nutr, Boston, MA 02115 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 203卷 / 01期

关键词：

COHORT; WOMEN;

D O I：

10.1093/infdis/jiq016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. We examined the baseline prevalence of penile, scrotal, perineal/perianal, and intra-anal human papillomavirus (HPV) infection in human immunodeficiency virus (HIV)-seronegative men who have sex with men (MSM). Methods. Data were analyzed from 602 MSM aged 16-27 years with <= 5 lifetime sexual partners. Serum samples were tested for antibodies to HPV6/11/16/18. Swab samples were collected separately from several anogenital areas for detection of HPV6/11/16/18/31/33/35/39/45/51/52/56/58/59 DNA. Results. The prevalence of any tested HPV type was 18.5% at the penis, 17.1% at the scrotum, 33.0% at the perineal/perianal region, 42.4% in the anal canal, and 48.0% at any site. Overall, 415 MSM (69.7%) were negative to HPV 6, 11, 16, and 18 at enrollment by both serology and DNA detection. Men residing in Europe and Latin America had significantly increased risk of HPV infection at external genital sites and the anal canal compared to men from Australia. Tobacco use and greater number of lifetime sexual partners was associated with higher HPV infection prevalence. Conclusions. The prevalence of HPV infection is high among young sexually active MSM, with the anal canal being the most common site of infection. Lifetime number of sexual partners was the most important modifiable risk factor for anogenital HPV infection.

引用

页码：66 / 74

页数：9

共 17 条

[1] Age-specific prevalence of anal human papillomavirus infection in HIV-Negative sexually active men who have sex with men: The EXPLORE study [J].