Initial impact of the sequencing of the human genome

被引：651

作者：

Lander, Eric S. ^{[1
,2
]}

机构：

[1] MIT, Broad Inst, Cambridge, MA 02142 USA

[2] Harvard Univ, Cambridge Ctr 7, Cambridge, MA 02142 USA

来源：

NATURE | 2011年 / 470卷 / 7333期

关键词：

HAPLOTYPE STRUCTURE; FETAL-HEMOGLOBIN; WIDE ASSOCIATION; SMALL MOLECULES; GENE; MUTATIONS; EXPRESSION; REVEALS; CANCER; LOCI;

D O I：

10.1038/nature09792

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The sequence of the human genome has dramatically accelerated biomedical research. Here I explore its impact, in the decade since its publication, on our understanding of the biological functions encoded in the genome, on the biological basis of inherited diseases and cancer, and on the evolution and history of the human species. I also discuss the road ahead in fulfilling the promise of genomics for medicine.

引用

页码：187 / 197

页数：11

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