The -491 TT apolipoprotein E promoter polymorphism is associated with reduced risk for sporadic Alzheimer's disease

被引：17

作者：

Alvarez-Arcaya, A

Combarros, O ^{[1
]}

Llorca, J

Sánchez-Guerra, M

Berciano, J

Fernández-Luna, JL

机构：

[1] Univ Hosp Marques de Valdecilla, Neurol Serv, Santander 39008, Spain

[2] Univ Cantabria, Sch Med, Div Prevent Med, Santander 39008, Spain

[3] Univ Hosp Marques de Valdecilla, Serv Immunol, Santander 39008, Spain

来源：

NEUROSCIENCE LETTERS | 2001年 / 304卷 / 03期

关键词：

Alzheimer's disease; -491 A/T polymorphism; apolipoprotein E; polymorphisms;

D O I：

10.1016/S0304-3940(01)01790-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Homozygosity for the A allele of the -491 A/T apolipoprotein E (APOE) promoter polymorphism has recently been reported to be associated with sporadic Alzheimer's disease (AD). Two hundred and fifty one patients with AD and an equal number of controls derived from the same region in a Spanish population, were genotyped for -491 A/T and epsilon2/ epsilon3/epsilon4 APOE polymorphisms. We did not detect an elevated -491 AA genotype frequency when comparing AD cases to controls. In contrast, persons homozygous for the T allele were at a significantly reduced risk of AD (odds ratio of 0.10, P = 0.006). Multiple logistic regression analysis indicated that the -491 TT polymorphism added information on the risk of AD which was independent of that of the APOE epsilon4 allele. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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页码：204 / 208

页数：5

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