共 53 条
Double stimuli-responsive cellulose nanocrystals reinforced electrospun PHBV composites membrane for intelligent drug release
被引:48
作者:
Chen, Yuxiang
[1
]
Abdalkarim, Somia Yassin Hussain
[1
,2
]
Yu, Hou-Yong
[1
,3
]
Li, Yingzhan
[1
]
Xu, Jiaxin
[3
]
Marek, Jaromir
[4
]
Yao, Juming
[1
]
Tam, Kam Chiu
[3
]
机构:
[1] Zhejiang Sci Tech Univ, Key Lab Adv Text Mat & Mfg Technol, Zhejiang Prov Key Lab Fiber Mat & Mfg Technol, Minist Educ, Xiasha Higher Educ Pk Ave 2 928, Hangzhou 310018, Peoples R China
[2] Zhejiang Sci Tech Univ, Coll Mech & Automat Control, Zhejiang Inst Technol & Automat Control, Hangzhou 310018, Peoples R China
[3] Univ Waterloo, Waterloo Inst Nanotechnol, Dept Chem Engn, 200 Univ Ave West, Waterloo, ON, Canada
[4] Inst Nanomat Adv Technol & Innovat, Studentska 1402-2, Liberec, Czech Republic
关键词:
Cellulose nanocrystals;
Nanofiber membrane;
Electrospinning;
Drug release;
DELIVERY-SYSTEMS;
POLY(VINYL ALCOHOL);
SCAFFOLDS;
NANOFIBERS;
POLYCAPROLACTONE;
NANOPARTICLES;
ADSORPTION;
POLYMERS;
MODEL;
D O I:
10.1016/j.ijbiomac.2020.03.216
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Double stimuli-responsive functionalized cellulose nanocrystal-poly[2-(dimethylamino)ethyl methacrylate] (CNC-g-PDMAEMA) reinforced poly(3-hydroxybutyrate-co-3-hydroxy valerate) (PHBV) electrospun composite membranes were explored as drug delivery vehicles using tetracycline hydrochloride (TH) as a model drug. It was found that rigid CNC-g-PDMAEMA nanoparticles enhanced thermal, crystallization and hydrophilic properties of PHBV. Moreover, great improvements in fiber diameter uniformity, crystallization ability and maximum decomposition temperature (T-max) could be achieved at 6 wt% CNC-g-PDMAEMA. Furthermore, by introducing stimuli-responsive CNC-g-PDMAEMA nanofillers, intelligent and long-term sustained release behavior of composite membranes could be achieved. The releasing mechanism of composite membranes based on zero order, first order, Higuchi and Korsmeyere-Peppas mathematical models was clearly demonstrated, giving effective technical guidance for practical drug delivery systems. (C) 2020 Elsevier B.V. All rights reserved.
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页码:330 / 339
页数:10
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