Double stimuli-responsive cellulose nanocrystals reinforced electrospun PHBV composites membrane for intelligent drug release

被引:48
作者
Chen, Yuxiang [1 ]
Abdalkarim, Somia Yassin Hussain [1 ,2 ]
Yu, Hou-Yong [1 ,3 ]
Li, Yingzhan [1 ]
Xu, Jiaxin [3 ]
Marek, Jaromir [4 ]
Yao, Juming [1 ]
Tam, Kam Chiu [3 ]
机构
[1] Zhejiang Sci Tech Univ, Key Lab Adv Text Mat & Mfg Technol, Zhejiang Prov Key Lab Fiber Mat & Mfg Technol, Minist Educ, Xiasha Higher Educ Pk Ave 2 928, Hangzhou 310018, Peoples R China
[2] Zhejiang Sci Tech Univ, Coll Mech & Automat Control, Zhejiang Inst Technol & Automat Control, Hangzhou 310018, Peoples R China
[3] Univ Waterloo, Waterloo Inst Nanotechnol, Dept Chem Engn, 200 Univ Ave West, Waterloo, ON, Canada
[4] Inst Nanomat Adv Technol & Innovat, Studentska 1402-2, Liberec, Czech Republic
关键词
Cellulose nanocrystals; Nanofiber membrane; Electrospinning; Drug release; DELIVERY-SYSTEMS; POLY(VINYL ALCOHOL); SCAFFOLDS; NANOFIBERS; POLYCAPROLACTONE; NANOPARTICLES; ADSORPTION; POLYMERS; MODEL;
D O I
10.1016/j.ijbiomac.2020.03.216
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Double stimuli-responsive functionalized cellulose nanocrystal-poly[2-(dimethylamino)ethyl methacrylate] (CNC-g-PDMAEMA) reinforced poly(3-hydroxybutyrate-co-3-hydroxy valerate) (PHBV) electrospun composite membranes were explored as drug delivery vehicles using tetracycline hydrochloride (TH) as a model drug. It was found that rigid CNC-g-PDMAEMA nanoparticles enhanced thermal, crystallization and hydrophilic properties of PHBV. Moreover, great improvements in fiber diameter uniformity, crystallization ability and maximum decomposition temperature (T-max) could be achieved at 6 wt% CNC-g-PDMAEMA. Furthermore, by introducing stimuli-responsive CNC-g-PDMAEMA nanofillers, intelligent and long-term sustained release behavior of composite membranes could be achieved. The releasing mechanism of composite membranes based on zero order, first order, Higuchi and Korsmeyere-Peppas mathematical models was clearly demonstrated, giving effective technical guidance for practical drug delivery systems. (C) 2020 Elsevier B.V. All rights reserved.
引用
收藏
页码:330 / 339
页数:10
相关论文
共 53 条
[1]   Thermo and light-responsive phase change nanofibers with high energy storage efficiency for energy storage and thermally regulated on-off drug release devices [J].
Abdalkarim, Somia Yassin Hussain ;
Yu, Houyong ;
Wang, Chuang ;
Chen, Yuxiang ;
Zou, Zhuanyong ;
Han, Lian ;
Yao, Juming ;
Tam, Kam Chiu .
CHEMICAL ENGINEERING JOURNAL, 2019, 375
[2]   Electrospun poly(3-hydroxybutyrate-co-3-hydroxy-valerate)/cellulose reinforced nanofibrous membranes with ZnO nanocrystals for antibacterial wound dressings [J].
Abdalkarim, Somia Yassin Hussain ;
Yu, Hou-Yong ;
Wang, Duanchao ;
Yao, Juming .
CELLULOSE, 2017, 24 (07) :2925-2938
[3]   Chemical modification of chitin by grafting with polystyrene using ammonium persulfate initiator [J].
Abu Naim, Ahmedy ;
Umar, Abdulganiyu ;
Sanagi, Mohd Marsin ;
Basaruddin, Noraimi .
CARBOHYDRATE POLYMERS, 2013, 98 (02) :1618-1623
[4]   Electrospun matrices for localised controlled drug delivery: release of tetracycline hydrochloride from layers of polycaprolactone and poly(ethylene-co-vinyl acetate) [J].
Alhusein, Nour ;
Blagbrough, Ian S. ;
De Bank, Paul A. .
DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 2012, 2 (06) :477-488
[5]   DLS and zeta potential - What they are and what they are not? [J].
Bhattacharjee, Sourav .
JOURNAL OF CONTROLLED RELEASE, 2016, 235 :337-351
[6]   Modeling and comparison of dissolution profiles [J].
Costa, P ;
Manuel, J ;
Lobo, S .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2001, 13 (02) :123-133
[7]   A comparative study of the stimuli-responsive properties of DMAEA and DMAEMA containing polymers [J].
Cotanda, Pepa ;
Wright, Daniel B. ;
Tyler, Martin ;
O'Reilly, Rachel K. .
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2013, 51 (16) :3333-3338
[8]   The Potential of Cellulose Nanocrystals in Tissue Engineering Strategies [J].
Domingues, Rui M. A. ;
Gomes, Manuela E. ;
Reis, Rui L. .
BIOMACROMOLECULES, 2014, 15 (07) :2327-2346
[9]   Advances in biopolymer-based membrane preparation and applications [J].
Galiano, Francesco ;
Briceno, Kelly ;
Marino, Tiziana ;
Molino, Antonio ;
Christensen, Knud Villy ;
Figoli, Alberto .
JOURNAL OF MEMBRANE SCIENCE, 2018, 564 :562-586
[10]   Hierarchically spacing DNA probes on bio-based nanocrystal for spatial detection requirements [J].
Gan, Lin ;
Wang, Ya ;
Zhang, Meng ;
Xia, Xuehuan ;
Huang, Jin .
SCIENCE BULLETIN, 2019, 64 (13) :934-940