Six insecticidal isoryanodane diterpenoids from the bark and twigs of Itoa orientalis

被引：23

作者：

Chai, Xing-Yun ^{[1
]}

Bai, Chang-Cai ^{[1
]}

Shi, Hai-Ming ^{[1
]}

Xu, Zheng-Ren ^{[1
]}

Ren, Hong-Yan ^{[1
]}

Li, Fei-Fei ^{[1
]}

Lu, Ya-Nan ^{[1
]}

Song, Yue-Lin ^{[1
]}

Tu, Peng-Fei ^{[1
]}

机构：

[1] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China

来源：

TETRAHEDRON | 2008年 / 64卷 / 24期

关键词：

itols A-D; isoryanodane glycosides; Itoa orientalis; X-ray diffraction; insecticidal activity;

D O I：

10.1016/j.tet.2008.04.022

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Four rare isoryanodane diterpenoids namely itols A-D (1-4) and two isoryanosdane glucosides (5 and 6) were isolated from the bark and twigs of Itoa orientalis. Their structures were determined by NMR and MS techniques and the Structure of 1 was confirmed by a single-crystal X-ray diffraction. These six diterpenoids obviously showed insecticidal activity against Spodoptera exigua, with LC(50) 28.62 ppm for 1 and 52.76 ppm for 2, respectively. In anti-inflammatory assay, compounds 1 and 4-6 showed anti-COX-2 activity, with inhibitory rates of 54.7-78.3% at 10 mu m. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：5743 / 5747

页数：5

共 12 条

[1]

Braulio M.F., 1997, J NAT PROD, V60, P880

[2]

Itosides A-I, new phenolic glycosides from Itoa orientalis [J].

Chai, Xing-Yun ;

Xu, Zheng-Ren ;

Ren, Hong-Yan ;

Shi, Hai-Ming ;

Lu, Ya-Nan ;

Li, Fei-Fei ;

Tu, Peng-Fei .

HELVETICA CHIMICA ACTA, 2007, 90 (11) :2176-2185

[3]

Cyclooxygenase inhibitors not inhibit resting lung cancer A549 cell proliferation [J].

Duan, Weigang ;

Zhang, Luyong .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2006, 74 (05) :317-321

[4]

Fan G.S., 1995, J SW FOREST COLL, V15, P1

[5]

Fu L.G., 1998, HIGHER PLANTS CHINA, V5, P110

[6]

Lai S.-S., 1994, B BOT RES HARBIN, V14, P221

[7]

Lu Lu, 2004, Acta Botanica Yunnanica, V26, P73

[8]

CINNCASSIOL D1 AND ITS GLUCOSIDE, NOVEL PENTACYCLIC DITERPENES FROM CINNAMOMI CORTEX [J].

NOHARA, T ;

KASHIWADA, Y ;

TOMIMATSU, T ;

KIDO, M ;

TOKUBUCHI, N ;

NISHIOKA, I .

TETRAHEDRON LETTERS, 1980, 21 (27) :2647-2648

[9]

Two new phenolic glycosides from the barks of Hydnocarpus annamensis and their anti-inflammatory and anti-oxidation activities [J].

Shi, Hai-Ming ;

Wen, Jing ;

Jia, Cun-Qin ;

Jin, Wei ;

Zhang, Xiu-Feng ;

Yao, Zhi-Rong ;

Tu, Peng-Fei .

PLANTA MEDICA, 2006, 72 (10) :948-950

[10]

SHI HM, NAT PROD RE IN PRESS

← 1 2 →