Repair of DNA covalently linked to protein

被引：76

作者：

Connelly, JC ^{[1
]}

Leach, DRF ^{[1
]}

机构：

[1] Univ Edinburgh, Inst Cell & Mol Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

MOLECULAR CELL | 2004年 / 13卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S1097-2765(04)00056-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A potentially lethal form of DNA/RNA modification, a cleavage complex, occurs when a nucleic acid-processing enzyme that acts via a transient covalent intermediate becomes trapped at its site of action. A number of overlapping pathways act to repair these lesions and many of the enzymes involved are those that catalyze recombinational-repair processes. A protein, Tdp1, has been identified that reverses cleavage-complex formation by specifically hydrolyzing a tyrosyl-DNA phosphodiester bond. The study of these pathways is both interesting and pertinent as they modulate the effectiveness of many antitumor/antibacterial drugs that act by stabilizing cleavage-complexes in vivo.

引用

页码：307 / 316

页数：10

共 53 条

[41]

Stohr BA, 2001, GENETICS, V158, P19

[42] Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex [J].

Stracker, TH ;

Carson, CT ;

Weitzman, MD .

NATURE, 2002, 418 (6895) :348-352

[43] Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy [J].

Takashima, H ;

Boerkoel, CF ;

John, J ;

Saifi, GM ;

Salih, MAM ;

Armstrong, D ;

Mao, YX ;

Quiocho, FA ;

Roa, BB ;

Nakagawa, M ;

Stockton, DW ;

Lupski, JR .

NATURE GENETICS, 2002, 32 (02) :267-272

[44] A DNA damage response pathway controlled by Tel1 and the Mre11 complex [J].

Usui, T ;

Ogawa, H ;

Petrini, JHJ .

MOLECULAR CELL, 2001, 7 (06) :1255-1266

[45] Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage [J].

Vance, JR ;

Wilson, TE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) :13669-13674

[46] Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3′ phosphatases [J].

Vance, JR ;

Wilson, TE .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (21) :7191-7198

[47] DNA topoisomerases [J].

Wang, JC .

ANNUAL REVIEW OF BIOCHEMISTRY, 1996, 65 :635-692

[48] ORIGIN OF CONCATEMERIC T7 DNA [J].

WATSON, JD .

NATURE-NEW BIOLOGY, 1972, 239 (94) :197-&

[49] Evidence that MutY is a monofunctional glycosylase capable of forming a covalent Schiff base intermediate with substrate DNA [J].

Williams, SD ;

David, SS .

NUCLEIC ACIDS RESEARCH, 1998, 26 (22) :5123-5133

[50]

Woodworth DL, 1996, GENETICS, V143, P1081

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