Glutamatergic animal models of schizophrenia

被引：118

作者：

Moghaddam, B ^{[1
]}

Jackson, ME ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15260 USA

来源：

GLUTAMATE AND DISORDERS OF COGNITION AND MOTIVATION | 2003年 / 1003卷

关键词：

NMDA receptors; schizophrenia; cognitions; dopamine; prefrontal cortex;

D O I：

10.1196/annals.1300.065

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Several lines of evidence, including recent genetic linkage studies implicating susceptibility genes for schizophrenia, make a strong case that abnormal NMDA receptor-mediated neurotransmission is a major locus for the pathophysiology of schizophrenia. Animal models that are relevant to putative NMDA dysfunction in schizophrenia have excellent face validity for several symptoms of schizophrenia and are important tools for the design of novel pharmacological intervention in schizophrenia. The present chapter includes a brief review of the utility of these models and the search for new medications that have the potential of normalizing glutamate neurotransmission in schizophrenia.

引用

页码：131 / 137

页数：7

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