Amine-catalyzed direct asymmetric Mannich-type reactions

被引：232

作者：

Notz, W

Sakthivel, K

Bui, T

Zhong, GF

Barbas, CF

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(00)01908-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three chiral cyclic secondary amines are shown to be catalysts for the direct asymmetric Mannich-type reaction of acetone with a variety of preformed aldimines derived from o-anisidine. A simple one-pot three-component reaction procedure consisting of aldehyde, acetone, p-anisidine and an amine catalyst provides the corresponding beta -amino ketones with 50-89% ee under very mild conditions. (C) 2000 Published by Elsevier Science Ltd.

引用

页码：199 / 201

页数：3

共 34 条

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