Multicenter Study of Isavuconazole MIC Distributions and Epidemiological Cutoff Values for the Cryptococcus neoformans-Cryptococcus gattii Species Complex Using the CLSI M27-A3 Broth Microdilution Method

被引：69

作者：

Espinel-Ingroff, A. ^{[1
]}

Chowdhary, A. ^{[2
]}

Gonzalez, G. M. ^{[3
]}

Guinea, J. ^{[4
]}

Hagen, F. ^{[5
]}

Meis, J. F. ^{[5
,6
]}

Thompson, G. R., III ^{[7
]}

Turnidge, J. ^{[8
]}

机构：

[1] VCU, Med Ctr, Richmond, VA 23284 USA

[2] Univ Delhi, Vallabhbhai Patel Chest Inst, Delhi 110007, India

[3] Univ Autonoma Nuevo Leon, Monterrey, Nuevo Leon, Mexico

[4] Univ Complutense, Sch Medicine, Hosp Gen Univ Gregorio Maranon, E-28040 Madrid, Spain

[5] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands

[6] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6525 ED Nijmegen, Netherlands

[7] Univ Calif Davis, Med Ctr, Davis, CA 95616 USA

[8] Univ Adelaide, Adelaide, SA, Australia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 01期

关键词：

ANTIFUNGAL SUSCEPTIBILITIES; POSACONAZOLE; VORICONAZOLE; FLUCONAZOLE; COLLECTION; DIVERSITY;

D O I：

10.1128/AAC.04055-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Epidemiological cutoff values (ECVs) of isavuconazole are not available for Cryptococcus spp. The isavuconazole ECVs based on wild-type (WT) MIC distributions for 438 Cryptococcus neoformans nongenotyped isolates, 870 isolates of genotype VNI, and 406 Cryptococcus gattii isolates from six laboratories and different geographical areas were 0.06, 0.12, and 0.25 mu g/ml, respectively. These ECVs may aid in detecting non-WT isolates with reduced susceptibilities to isavuconazole.

引用

页码：666 / 668

页数：3

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