Preparation of ethyl 5-iodo-1H-indole-2-carboxylate

被引:7
作者
Beshore, DC [1 ]
Dinsmore, CJ [1 ]
机构
[1] Merck Res Labs, Dept Med Chem, W Point, PA 19486 USA
关键词
indole; regioselective halogenation; dehalogenation;
D O I
10.1081/SCC-120021830
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A facile, two step procedure for the preparation of ethyl 5-iodo-1H-indole-2-carboxylate (1) from commercially available ethyl 1H-indole-2-carboxylate is described herein, employing a regioselective C3, C5-bisiodination followed by zinc-mediated C3-dehalogenation.
引用
收藏
页码:2423 / 2427
页数:5
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