Oxazolinyloxiranyllithium-mediated stereoselective synthesis of α-epoxy-β-amino acids

被引：29

作者：

Luisi, R

Capriati, V

Degennaro, L

Florio, S

机构：

[1] Univ Bari, Dipartimento Farmaco Chim, I-70126 Bari, Italy

[2] ICCOM, CNR, Bari, Italy

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 15期

关键词：

D O I：

10.1021/ol034927q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereoselective synthesis of novel alpha-epoxy-beta-amino acids is described by a route that combines the chemistry of oxazolinyloxiranyllithiums with that of nitrones. The intermediate trioxadiazadispiro[2.0.4.3]undecanes 4 have been isolated and converted by hydrolysis into epoxy-5-isoxazoildinones 5 which can be transformed into the alpha-epoxy-beta-amino acids 8 by N-O reduction.

引用

页码：2723 / 2726

页数：4

共 26 条

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