Decreased Clearance of CNS β-Amyloid in Alzheimer's Disease

被引:1596
作者
Mawuenyega, Kwasi G. [1 ]
Sigurdson, Wendy [1 ,2 ]
Ovod, Vitaliy [1 ]
Munsell, Ling [1 ]
Kasten, Tom [1 ]
Morris, John C. [1 ,2 ,3 ]
Yarasheski, Kevin E. [4 ]
Bateman, Randall J. [1 ,2 ,5 ]
机构
[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Alzheimers Dis Res Ctr, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[5] Washington Univ, Sch Med, Hope Ctr Neurol Disorders, St Louis, MO 63110 USA
关键词
IN-VIVO;
D O I
10.1126/science.1197623
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
[No abstract available]
引用
收藏
页码:1774 / 1774
页数:1
相关论文
共 7 条
[1]   Human amyloid-β synthesis and clearance rates as measured in cerebrospinal fluid in vivo [J].
Bateman, Randall J. ;
Munsell, Ling Y. ;
Morris, John C. ;
Swarm, Robert ;
Yarasheski, Kevin E. ;
Holtzman, David M. .
NATURE MEDICINE, 2006, 12 (07) :856-861
[2]   A γ-Secretase Inhibitor Decreases Amyloid-β Production in the Central Nervous System [J].
Bateman, Randall J. ;
Siemers, Eric R. ;
Mawuenyega, Kwasi G. ;
Wen, Guolin ;
Browning, Karen R. ;
Sigurdson, Wendy C. ;
Yarasheski, Kevin E. ;
Friedrich, Stuart W. ;
DeMattos, Ronald B. ;
May, Patrick C. ;
Paul, Steven M. ;
Holtzman, David M. .
ANNALS OF NEUROLOGY, 2009, 66 (01) :48-54
[3]   Drug therapy - Alzheimer's disease [J].
Cummings, JL .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (01) :56-67
[4]   ApoE and clusterin cooperatively suppress Aβ levels and deposition:: Evidence that ApoE regulates extracellular Aβ metabolism in vivo [J].
DeMattos, RB ;
Cirrito, JR ;
Parsadanian, M ;
May, PC ;
O'Dell, MA ;
Taylor, JW ;
Harmony, JAK ;
Aronow, BJ ;
Bales, KR ;
Paul, SM ;
Holtzman, DM .
NEURON, 2004, 41 (02) :193-202
[5]   Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience .15. [J].
Ellis, RJ ;
Olichney, JM ;
Thal, LJ ;
Mirra, SS ;
Morris, JC ;
Beekly, D ;
Heyman, A .
NEUROLOGY, 1996, 46 (06) :1592-1596
[6]   Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics [J].
Hardy, J ;
Selkoe, DJ .
SCIENCE, 2002, 297 (5580) :353-356
[7]   Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease [J].
Scheuner, D ;
Eckman, C ;
Jensen, M ;
Song, X ;
Citron, M ;
Suzuki, N ;
Bird, TD ;
Hardy, J ;
Hutton, M ;
Kukull, W ;
Larson, E ;
LevyLahad, E ;
Viitanen, M ;
Peskind, E ;
Poorkaj, P ;
Schellenberg, G ;
Tanzi, R ;
Wasco, W ;
Lannfelt, L ;
Selkoe, D ;
Younkin, S .
NATURE MEDICINE, 1996, 2 (08) :864-870