Variability and robustness in biomolecular systems

被引：82

作者：

Barkai, Naama ^{[1
]}

Shilo, Ben-Zion ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

来源：

MOLECULAR CELL | 2007年 / 28卷 / 05期

关键词：

D O I：

10.1016/j.molcel.2007.11.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The need to perform sophisticated information processing in an environment that is variable and noisy restricts the functional design of biological networks. We discuss several of the strategies that cells and multicellular organisms have evolved to deal with this demand.

引用

收藏

页码：755 / 760

页数：6

相关论文

共 38 条

[1] Robustness in bacterial chemotaxis [J].

Alon, U ;

Surette, MG ;

Barkai, N ;

Leibler, S .

NATURE, 1999, 397 (6715) :168-171

[2] Bacterial persistence as a phenotypic switch [J].

Balaban, NQ ;

Merrin, J ;

Chait, R ;

Kowalik, L ;

Leibler, S .

SCIENCE, 2004, 305 (5690) :1622-1625

[3] Noise in protein expression scales with natural protein abundance [J].

Bar-Even, Arren ;

Paulsson, Johan ;

Maheshri, Narendra ;

Carmi, Miri ;

O'Shea, Erin ;

Pilpel, Yitzhak ;

Barkai, Naama .

NATURE GENETICS, 2006, 38 (06) :636-643

[4] Robustness in simple biochemical networks [J].

Barkai, N ;

Leibler, S .

NATURE, 1997, 387 (6636) :913-917

[5] PHYSICS OF CHEMORECEPTION [J].

BERG, HC ;

PURCELL, EM .

BIOPHYSICAL JOURNAL, 1977, 20 (02) :193-219

[6] Pre-steady-state decoding of the bicoid morphogen gradient [J].

Bergmann, Sven ;

Sandler, Oded ;

Sberro, Hila ;

Shnider, Sara ;

Schejter, Eyal ;

Shilo, Ben-Zion ;

Barkai, Naama .

PLOS BIOLOGY, 2007, 5 (02) :232-242

[7] Phenotypic consequences of promoter-mediated transcriptional noise [J].

Blake, William J. ;

Balazsi, Gbor ;

Kohanski, Michael A. ;

Isaacs, Farren J. ;

Murphy, Kevin F. ;

Kuang, Yina ;

Cantor, Charles R. ;

Walt, David R. ;

Collins, James J. .

MOLECULAR CELL, 2006, 24 (06) :853-865

[8] Noise in eukaryotic gene expression [J].

Blake, WJ ;

Kærn, M ;

Cantor, CR ;

Collins, JJ .

NATURE, 2003, 422 (6932) :633-637

[9] Sara endosomes and the maintenance of Dpp signaling levels across mitosis [J].

Boekel, Christian ;

Schwabedissen, Anja ;

Entchev, Eugeni ;

Renaud, Olivier ;

Gonzalez-Gaitan, Marcos .

SCIENCE, 2006, 314 (5802) :1135-1139

[10] An ultrasensitive bacterial motor revealed by monitoring signaling proteins in single cells [J].

Cluzel, P ;

Surette, M ;

Leibler, S .

SCIENCE, 2000, 287 (5458) :1652-1655

← 1 2 3 4 →