Cell polarization mechanisms during directed cell migration

被引：68

作者：

Huttenlocher, A

机构：

[1] Univ Wisconsin, Dept Pharmacol, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Pediat, Madison, WI 53706 USA

来源：

NATURE CELL BIOLOGY | 2005年 / 7卷 / 04期

关键词：

D O I：

10.1038/ncb0405-336

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

How cells establish and maintain polarity during directed cell migration remains poorly understood. Nishiya et al. now describe an integrin signalling complex that includes paxillin and GIT1, which limits activation of Rac to the leading edge of a migrating cell.

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页码：336 / 337

页数：2

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