Three new ellagic acid derivatives from the bark of Eschweilera coriacea from the Suriname rainforest

被引:59
作者
Yang, SW
Zhou, BN
Wisse, JH
Evans, R
van der Werff, H
Miller, JS
Kingston, DGI [1 ]
机构
[1] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA
[2] Missouri Bot Garden, St Louis, MO 63166 USA
[3] Commissaris Roblesweg, Bedrijf Geneesmiddelen Voorziening Suriname, Geyersluit, Suriname
来源
JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 07期
关键词
D O I
10.1021/np980046u
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Bioassay-guided fractionation of Eschweilera coriacea collected in the lowland wet forest of Suriname yielded the new but only weakly active ellagic acid derivative eschweilenol A (1) and the two new but inactive ellagic acid derivatives eschweilenol B (2) and eschweilenol C (3). The four known compounds, sucrose, ellagic acid, 3-O-galloylepigallocatechin, and epigallocatechin, were also isolated. The structures of the three new compounds were determined by spectrometric methods, primarily from the HMQC, HMBC, NOESY, and ROESY NMR techniques, and chemical methods, including methylation and triethylsilylation. The location of a hydroxyl group in one ellagic acid derivative was determined by a new technique involving an NOE correlation of the protons of a triethylsilyl derivative with a proton on a neighboring aromatic ring.
引用
收藏
页码:901 / 906
页数:6
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