Nanogold-pharmaceutics -: (i) The use of colloidal gold to treat experimentally-induced arthritis in rat models;: (ii) Characterization of the gold in Swarna bhasma, a micro particulate used in traditional Indian medicine

被引：67

作者：

Brown, Christopher L. ^{[1
]}

Bushell, Gillian

Whitehouse, Michael W.

Agrawal, D. S.

Tupe, S. G.

Paknikar, K. M.

Tiekink, Edward R. T.

机构：

[1] Griffith Univ, Fac Sci, Nathan, Qld 4111, Australia

[2] Agharkar Res Inst, Microbia Sci Div, Pune 411004, Maharashtra, India

[3] Univ Texas, Dept Chem, San Antonio, TX 78249 USA

来源：

GOLD BULLETIN | 2007年 / 40卷 / 03期

关键词：

gold; nanoparticle; experimental arthritis; ayurvedic medicine; aurothiomalate; ANTITUMOR-ACTIVITY; DOUBLE-BLIND; NANOPARTICLES; THERAPY; AGENTS; CYTOTOXICITY; DERIVATIVES; COMPLEXES; SURFACE; DRUGS;

D O I：

10.1007/BF03215588

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Nanosized gold particles (27 +/- 3 nm) have been proven to be effective in ameliorating the symptoms of mycobacterial-, collagen- and pristane-induced arthritis in rat models. This contrasts with the drug sodium aurothiomalate that was only effective against mycobacterial-induced arthritis but not to the same extent as Au-0. Gold in the traditional Indian Ayurvedic medicine, Swama bhasma (gold ash), has been characterized as globular particles of gold with an average size of 56-57 nm.

引用

页码：245 / 250

页数：6

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