Short-term effects of leptin on lipid metabolism in the rat

被引：27

作者：

López-Soriano, J ^{[1
]}

Carbó, N ^{[1
]}

López-Soriano, FJ ^{[1
]}

Argilés, JM ^{[1
]}

机构：

[1] Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, E-08071 Barcelona, Spain

来源：

FEBS LETTERS | 1998年 / 431卷 / 03期

关键词：

leptin; lipogenesis; lipoprotein lipase; triacylglycerol; adipose tissue; skeletal muscle;

D O I：

10.1016/S0014-5793(98)00784-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we have examined the short-term effects of leptin on lipid metabolism in the rat. Acute leptin administration induced hypertriglyceridaemia (31% increase in plasma triacylglycerols) which was not associated with changes in lipoprotein lipase activity in white adipose tissue. Surprisingly, leptin administration did not induce any changes in the lipogenic rate in either white adipose tissue or liver. Leptin administration caused a decreased tissue uptake of exogenous C-14-triacyclglycerols, These data suggest that leptin induces important changes in lipid uptake in adipose tissue and skeletal muscle which could be responsible for the observed hypertriglyceridaemia. (C) 1998 Federation of European Biochemical Societies.

引用

页码：371 / 374

页数：4

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