1,3,4-Thiadiazole Based Anticancer Agents

被引：52

作者：

Aliabadi, Alireza ^{[1
,2
]}

机构：

[1] Kermanshah Univ Med Sci, Sch Pharm, Pharmaceut Sci Res Ctr, Kermanshah, Iran

[2] Kermanshah Univ Med Sci, Fac Pharm, Dept Med Chem, Kermanshah, Iran

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 10期

关键词：

1,3,4-Thiadiazole; anticancer; cytotoxicity; cell lines; IN-VITRO ANTICANCER; BIOLOGICAL EVALUATION; ANTIPROLIFERATIVE ACTIVITY; CYTOTOXIC ACTIVITIES; MOLECULAR DOCKING; CRYSTAL-STRUCTURE; DERIVATIVES; ANTITUMOR; ANALOGS; TRIAZOLOTHIADIAZOLE;

D O I：

10.2174/1871520616666160628100936

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In recent years, researchers like medicinal chemists in the field of medicinal chemistry have widely utilized the 1,3,4-thiadiazole nucleus to investigate its biological and pharmacological effects. This heterocyclic structure has demonstrated various bioactivities such as antifungal, antimicrobial, antiviral, antileishmanial, anti-inflammatory, antihypertensive, antiepileptic, and anticancer effects among others. Anticancer activity is one of its promising effect as five membered heterocyclic rings have widely been investigated by researchers in the recent years. Herein, we reviewed the chemical structures bearing 1,3,4-thiadiazole template exerting anticancer activity.

引用

页码：1301 / 1314

页数：14

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