In vitro activities of 25 quinolones and fluoroquinolones against liver and blood stage Plasmodium spp.

被引：64

作者：

Mahmoudi, N

Ciceron, L

Franetich, JF

Farhati, K

Silvie, O

Eling, W

Sauerwein, R

Danis, M

Mazier, D

Derouin, F

机构：

[1] Univ Paris 06, Assistance Publ Hop Paris, CHU Pitie Salpetriere, INSERM,U511, F-75013 Paris, France

[2] Assistance Publ Hop Paris, Lab Parasitol Mycol, F-75010 Paris, France

[3] Assistance Publ Hop Paris, St Louis Hosp, F-75010 Paris, France

[4] Univ Nijmegen, Dept Med Microbiol, Nijmegen, Netherlands

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 08期

关键词：

D O I：

10.1128/AAC.47.8.2636-2639.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro activities of 25 quinolones and fluoroquinolones against erythrocytic stages of Plasmodium falciparum and against liver stages of Plasmodium yoelii yoelii and P. falciparum were studied. All compounds were inhibitory for chloroquine-sensitive and chloroquine-resistant P. falciparum grown in red blood cells. This inhibitory effect increased with prolonged incubation and according to the logarithm of the drug concentration. Grepafloxacin, trovafloxacin, and ciprofloxacin were the most effective drugs, with 50% inhibitory concentrations of <10 μg/ml against both strains. Only grepafloxacin, piromidic acid, and trovafloxacin had an inhibitory effect against hepatic stages of P. falciparum and P. yoelii yoelii; this effect combined reductions of the numbers and the sizes of schizonts in treated cultures. Thus, quinolones have a potential for treatment or prevention of malaria through their unique antiparasitic effect against erythrocytic and hepatic stages of Plasmodium.

引用

页码：2636 / 2639

页数：4

共 23 条

[1] Assessment of pyronaridine activity in vivo and in vitro against the hepatic stages of malaria in laboratory mice [J].