The potential role of innate immunity in the pathogenesis of Hodgkin's lymphoma

被引：28

作者：

Enblad, Gunila ^{[1
]}

Molin, Daniel

Glimelius, Ingrid

Fischer, Marie

Nilsson, Gunnar

机构：

[1] Uppsala Univ, Dept Oncol Radiol & Clin Immunol, Sect Oncol, Rudbeck Lab C11, S-75185 Uppsala, Sweden

[2] Karolinska Inst, Dept Med, S-17176 Stockholm, Sweden

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2007年 / 21卷 / 05期

关键词：

D O I：

10.1016/j.hoc.2007.07.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The innate immune system is our first line of defense against danger signals but in Hodgkin's lymphoma the role seems opposite, favoring malignant development. In this article we describe interactions between Hodgkin's and Reed-Sternberg cells and the cells of the innate immune system: eosinophils, mast cells, neutrophils, and macrophages. These cells clearly contribute to the pathogenesis of this disease and to the prognosis. Cytokines and chemokines released from the activated immune cells probably promote tumor cell growth and survival along with angiogenesis. Mast cells and eosinophils seem also to contribute to the fibrosis that is so characteristic for nodular sclerosis.

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页码：805 / +

页数：20

相关论文

共 98 条

[1] Interactions between tissue fibroblasts in lymph nodes and Hodgkin/Reed-Sternberg cells [J].

Aldinucci, D ;

Lorenzon, D ;

Olivo, K ;

Rapanà, B ;

Gattei, V .

LEUKEMIA & LYMPHOMA, 2004, 45 (09) :1731-1739

[2] Hodgkin and Reed-Sternberg cells express functional c-kit receptors and interact with primary fibroblasts from Hodgkin's disease-involved lymph nodes through soluble and membrane-bound stem cell factor [J].

Aldinucci, D ;

Poletto, D ;

Nanni, P ;

Degan, M ;

Gloghini, A ;

Di Francia, R ;

Russo, S ;

Carbone, A ;

Pinto, A ;

Gattei, V .

BRITISH JOURNAL OF HAEMATOLOGY, 2002, 118 (04) :1055-1064

[3] ATOPY - A FAVORABLE PROGNOSTIC FACTOR FOR SURVIVAL IN HODGKINS-DISEASE [J].

AMLOT, PL ;

SLANEY, J ;

BROWN, R .

BRITISH JOURNAL OF CANCER, 1983, 48 (02) :209-215

[4] Biological markers may add to prediction of outcome achieved by the international prognostic score in Hodgkin's disease [J].

Axdorph, U ;

Sjöberg, J ;

Grimfors, G ;

Landgren, O ;

Porwit-MacDonald, A ;

Björkholm, M .

ANNALS OF ONCOLOGY, 2000, 11 (11) :1405-1411

[5] Tissue eosinophilia in relation to immunopathological and clinical characteristics in Hodgkin's disease [J].

Axdorph, U ;

Porwit-MacDonald, A ;

Grimfors, G ;

Björkholm, M .

LEUKEMIA & LYMPHOMA, 2001, 42 (05) :1055-+

[6] Inflammation and cancer: back to Virchow? [J].

Balkwill, F ;

Mantovani, A .

LANCET, 2001, 357 (9255) :539-545

[7] ULTRASTRUCTURAL IMMUNOGOLD LOCALIZATION OF TUMOR-NECROSIS-FACTOR-ALPHA TO THE MATRIX COMPARTMENT OF EOSINOPHIL SECONDARY GRANULES IN PATIENTS WITH IDIOPATHIC HYPEREOSINOPHILIC SYNDROME [J].

BEIL, WJ ;

WELLER, PF ;

TZIZIK, DM ;

GALLI, SJ ;

DVORAK, AM .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1993, 41 (11) :1611-1615

[8] Poor clinical outcome of patients with Hodgkin's Disease and elevated interleukin-10 serum levels - Clinical significance of interleukin-l0 serum levels for Hodgkin's disease [J].

Bohlen, H ;

Kessler, M ;

Sextro, M ;

Diehl, V ;

Tesch, H .

ANNALS OF HEMATOLOGY, 2000, 79 (03) :110-113

[9] CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the nonneoplastic leukocytic infiltrates of Hodgkin disease [J].

Buri, C ;

Körner, M ;

Schärli, P ;

Cefai, D ;

Uguccioni, M ;

Mueller, C ;

Laissue, JA ;

Mazzucchelli, L .

BLOOD, 2001, 97 (06) :1543-1548

[10] The bactericidal/permeability-increasing protein (BPI) is present in specific granules of human eosinophils [J].

Calafat, J ;

Janssen, H ;

Tool, A ;

Dentener, MA ;

Knol, EF ;

Rosenberg, HF ;

Egesten, A .

BLOOD, 1998, 91 (12) :4770-4775

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