Involvement of multiple genetic loci in Staphylococcus aureus teicoplanin resistance

被引：8

作者：

Bischoff, M

Roos, M

Putnik, J

Wada, A

Glanzmann, P

Giachino, P

Vaudaux, P

Berger-Bächi, B

机构：

[1] Univ Zurich, Inst Med Microbiol, CH-8028 Zurich, Switzerland

[2] Robert Koch Inst, D-13353 Berlin, Germany

[3] Univ Hosp Geneva, Div Infect Dis, CH-1211 Geneva, Switzerland

来源：

FEMS MICROBIOLOGY LETTERS | 2001年 / 194卷 / 01期

关键词：

teicoplanin resistance; sigB; pigment; cell wall; Staphylococcus aureus;

D O I：

10.1111/j.1574-6968.2001.tb09449.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Teicoplanin resistance was transformed from a teicoplanin-resistant Staphylococcus aureus into the susceptible strain BB255 to give strain BB938. The cell wall composition, amidation of the iD-glutamate, and peptide crosslinking were identical in BB938 as in BB255 except for a 60% increased length of the glycan chain. Transductional crosses revealed that at least two distinct loci contributed in a cumulative fashion to teicoplanin resistance. One of these loci correlated with a mutation inactivating the anti-sigma factor RsbW. This mutation must have occurred during transformation and selection for teicoplanin resistance in BB938. Genetic manipulations involving the sigB operon showed that transcription factor SigB contributed to decreased teicoplanin susceptibility. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：77 / 82

页数：6

共 22 条

[1]

[Anonymous], [No title captured]

[2] PHYSICAL MAPPING OF THE BGLI, BGLII, PSTI AND ECORI RESTRICTION FRAGMENTS OF STAPHYLOCOCCAL PHAGE PHI11 DNA [J].