Post-transplantation osteoporosis

被引：79

作者：

Stein, Emily

Ebeling, Peter

Shane, Elizabeth

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Med, Div Endocrinol, New York, NY 10032 USA

[2] Univ Melbourne, Western Hosp, Dept Med, Footscray, Vic 3011, Australia

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2007年 / 36卷 / 04期

关键词：

D O I：

10.1016/j.ecl.2007.07.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Osteoporosis is prevalent in transplant recipients and is related to pre- and post-transplantation factors. Low bone density and fractures may antedate transplantation, related to traditional risk factors for osteoporosis, effects of chronic illness, and end-stage organ failure and its therapy, on the skeleton. Bone loss after transplantation is related to adverse effects of immunosuppressive drugs (glucocorticoids and calcineurin inhibitors) on bone remodeling. Newer immunosuppressive medications may permit lower doses of glucocorticoids and may be associated with decreased bone loss and fractures. Bisphosphonates are currently the most effective agents for the prevention and treatment of post-transplantation osteoporosis.

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页码：937 / +

页数：28

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