Finding specific genes that cause autism: A combination of approaches will be needed to maximize power

被引：18

作者：

Folstein, SE

Bisson, E

Santangelo, SL

Piven, J

机构：

[1] Tufts Univ, New England Med Ctr Hosp, Sch Med, Dept Psychiat, Boston, MA 02111 USA

[2] Univ Iowa, Coll Med, Dept Psychiat, Iowa City, IA 52242 USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 1998年 / 28卷 / 05期

关键词：

genetic methods; genetic linkage; sib-pair analysis; extremely discordant sibling pairs;

D O I：

10.1023/A:1026008606672

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Although autism is clearly inherited, it may be challenging to find the genes involved: The mechanism of inheritance is unknown, families with an autistic child are usually small, parent-child pairs are rare, and a fairly large number of genes may be involved, some or all of which may have a small effect on the phenotype. We discuss several strategies for finding genes, all of which may be used in combination to find the relevant genes.

引用

页码：439 / 445

页数：7

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