The TNF receptor family member CD30 is not essential for negative selection

被引：39

作者：

DeYoung, AL

Duramad, O

Winoto, A ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Div Immunol, LSA, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Canc Res Lab, Berkeley, CA 94720 USA

来源：

JOURNAL OF IMMUNOLOGY | 2000年 / 165卷 / 11期

关键词：

D O I：

10.4049/jimmunol.165.11.6170

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD30 is a member of the TNF receptor superfamily that has been implicated in negative selection and some forms of peripheral tolerance. A previous study of CD30(-/-) mice in a class I-restricted H-Y TCR-transgenic mouse model showed that CD30 is essential for removal of autoreactive thymocytes, During the course of the studies of CD30 in the class II-restricted TCR-transgenic mice, we found that the absence of CD30 has no effect on negative selection. Surprisingly, we also found that the CD30 mutation does not perturb apoptosis of the autoreactive thymocytes in the class I-restricted H-Y TCR-transgenic model. The minimal role of CD30 in negative selection and other recent data are discussed.

引用

页码：6170 / 6173

页数：4

共 29 条

[1] Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice [J].