Flow NMR applications in combinatorial chemistry

被引:27
作者
Keifer, PA [1 ]
机构
[1] Univ Nebraska, Nebraska Med Ctr 986805, Eppley Inst, Omaha, NE 68198 USA
关键词
D O I
10.1016/S1367-5931(03)00051-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Flow NMR techniques are now well accepted and widely used in many areas of drug discovery. Although natural-product-, rational-drug-design-, and NMR-screening-programs have begun to use flow NMR more routinely, flow NMR has not yet gained widespread acceptance in combinatorial chemistry, even though it has been shown to be a potentially useful tool. Recent developments in DI-NMR, FIA-NMR, and LC-NMR will help flow NMR eventually gain a wider acceptance within combinatorial chemistry. These developments include LC-NMR-MS instrumentation, flow probe improvements, new pulse sequences, improved automation of NMR data analysis, and the application of flow NMR to related fields in drug discovery.
引用
收藏
页码:388 / 394
页数:7
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