An increase of mature type skin collagen cross-link, histidinohydroxylysinonorleucine, in the sclerotic skin of morphea

被引：1

作者：

Tamura, M ^{[1
]}

Ishikawa, O ^{[1
]}

机构：

[1] Gunma Univ, Sch Med, Dept Dermatol, Gunma 3718511, Japan

来源：

JOURNAL OF DERMATOLOGICAL SCIENCE | 2001年 / 25卷 / 01期

关键词：

histidinohydroxylysinonorleucine; collagen; cross-link; morphea; reversed-phase high performance liquid chromatography;

D O I：

10.1016/S0923-1811(00)00112-2

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Histidinohydroxylysinonorleucine (HHL) is a trivalent cross-link of type I collagen that is stable and has physiologic properties. In this study, we conducted a biochemical quantification of HHL in five patients with morphea. We compared the quantity of HHL contained in the lesional skin and the adjacent normal skin. The molar ratio of HHL to collagen in the sclerotic lesion was significantly higher than that of the adjacent normal skin (0.36 +/- 0.09 vs. 0.28 +/- 0.10, P < 0.01). We could find no relationship between an increase of HHL content and the duration of the disease. The results indicate that an increased amount of HHL may play a certain role to inducing the sclerotic skin change characteristic of morphea. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：83 / 86

页数：4

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