Gene-environment interaction in Alzheimer's disease: A potential role for cholesterol

被引：44

作者：

Chandra, V

Pandav, R

机构：

[1] Ctr Ageing Res, New Delhi 110057, India

[2] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA

来源：

NEUROEPIDEMIOLOGY | 1998年 / 17卷 / 05期

关键词：

Alzheimer's disease; environment; genes; gene-environment interaction; cholesterol; apolipoprotein;

D O I：

10.1159/000026175

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Alzheimer's disease is probably a complex disease caused by an interaction of multiple environmental and genetic factors. Genetic defects include 'causative' genes which are rare and a 'susceptibility' gene (epsilon 4 allele of apolipoprotein E) which is more common in cases. Recent research suggests that environmental factors may interact with a genetic predisposition to modify the risk of Alzheimer's disease. An interaction between serum cholesterol levels and epsilon 4 genotype is proposed. The evidence for this gene-environment interaction is discussed.

引用

页码：225 / 232

页数：8

共 62 条

[1]

BARODAWALA SA, 1992, CURR SCI INDIA, V63, P449

[2]

BERGEM ALM, 1994, CLIN GENET, V46, P144

[3]

BHATNAGAR D, 1995, LANCET, V345, P405

[4]

Bodovitz S, 1996, J BIOL CHEM, V271, P4436

[5]

BOERWINKLE E, 1988, AM J HUM GENET, V42, P104

[6] ALZHEIMERS-DISEASE IN THE NATIONAL-ACADEMY-OF-SCIENCES NATIONAL RESEARCH COUNCIL REGISTRY OF AGING TWIN VETERANS .3. DETECTION OF CASES, LONGITUDINAL RESULTS, AND OBSERVATIONS ON TWIN CONCORDANCE [J].

BREITNER, JCS ;

WELSH, KA ;

GAU, BA ;

MCDONALD, WM ;

STEFFENS, DC ;

SAUNDERS, AM ;

MAGRUDER, KM ;

HELMS, MJ ;

PLASSMAN, BL ;

FOLSTEIN, MF ;

BRANDT, J ;

ROBINETTE, CD ;

PAGE, WF .

ARCHIVES OF NEUROLOGY, 1995, 52 (08) :763-771

[7]

BRESLOW JL, 1982, J LIPID RES, V23, P1224

[8] PROTECTIVE EFFECT OF APOLIPOPROTEIN-E TYPE-2 ALLELE FOR LATE-ONSET ALZHEIMER-DISEASE [J].

CORDER, EH ;

SAUNDERS, AM ;

RISCH, NJ ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

RIMMLER, JB ;

LOCKE, PA ;

CONNEALLY, PM ;

SCHMADER, KE ;

SMALL, GW ;

ROSES, AD ;

HAINES, JL ;

PERICAKVANCE, MA .

NATURE GENETICS, 1994, 7 (02) :180-184

[9] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].

CORDER, EH ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

SMALL, GW ;

ROSES, AD ;

HAINES, JL ;

PERICAKVANCE, MA .

SCIENCE, 1993, 261 (5123) :921-923

[10]

EHNHOLM C, 1986, J LIPID RES, V27, P277

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