Wound Healing and Skin Regeneration

被引：546

作者：

Takeo, Makoto ^{[1
,2
]}

Lee, Wendy ^{[1
,2
]}

Ito, Mayumi ^{[1
,2
]}

机构：

[1] NYU, Sch Med, Ronald O Perelman Dept Dermatol, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2015年 / 5卷 / 01期

基金：

美国国家卫生研究院;

关键词：

HAIR FOLLICLE NEOGENESIS; MELANOCYTE STEM-CELLS; LABEL-RETAINING CELLS; FETAL WOUNDS; TGF-BETA; GROWTH; DISTINCT; BULGE; MICE; ACTIVATION;

D O I：

10.1101/cshperspect.a023267

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The skin is a complex organ consisting of the epidermis, dermis, and skin appendages, including the hair follicle and sebaceous gland. Wound healing in adult mammals results in scar formation without any skin appendages. Studies have reported remarkable examples of scarless healing in fetal skin and appendage regeneration in adult skin following the infliction of large wounds. The models used in these studies have offered a new platform for investigations of the cellular and molecular mechanisms underlying wound healing and skin regeneration in mammals. In this article, we will focus on the contribution of skin appendages to wound healing and, conversely, skin appendage regeneration following injuries.

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