The public health impact of prion diseases

被引：57

作者：

Belay, ED ^{[1
]}

Schonberger, LB ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA

来源：

ANNUAL REVIEW OF PUBLIC HEALTH | 2005年 / 26卷

关键词：

transmissible spongiform encephalopathy; Creutzfeldt-Jakob disease; variant Creutzfeldt-Jakob disease; bovine spongiform encephalopathy; chronic wasting disease;

D O I：

10.1146/annurev.publhealth.26.021304.144536

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Several prion disease-related human health risks from an exogenous source can be identified in the United States, including the iatrogenic transmission of Creutzfeldt-Jakob disease (CJD), the possible occurrence of variant CJD (vCJD), and potential zoonotic transmission of chronic wasting disease (CWD). Although cross-species transmission of prion diseases seems to be limited by an apparent "species barrier," the occurrence of bovine spongiform encephalopathy (BSE) and its transmission to humans indicate that animal prion diseases can pose a significant public health risk. Recent reports of secondary person-to-person spread of vCJD via blood products and detection of vCJD transmission in a patient heterozygous at codon 129 further illustrate the potential public health impacts of BSE.

引用

页码：191 / 212

页数：22

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[1] EXCEPTIONALLY SMALL SIZE OF SCRAPIE AGENT [J].