RNA editing: cytidine to uridine conversion in apolipoprotein B mRNA

被引：68

作者：

Chester, A

Scott, J

Anant, S

Navaratnam, N

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Ctr Clin Sci, MRC Mol Med, London W12 0NN, England

[2] Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2000年 / 1494卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

RNA editing; apolipoprotein B; APOBEC-1; cancer RNA;

D O I：

10.1016/S0167-4781(00)00219-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA editing is a post-transcriptional process that changes the informational capacity within the RNA. These processes include alterations made by nucleotide deletion, insertion and base conversion. A to I and C to U conversion occurs in mammals and these editing events are catalysed by RNA. binding deaminases. C to U editing of apoB mRNA was the first mammalian editing event to be identified. The minimal protein complex necessary for apoB mRNA editing has been determined and consists of APOBEC-1 and ACF. Overexpression of APOBEC-1 in transgenic animals caused liver dysplasia and APOBEC-I has been identified in neurofibromatosis type I tumours, suggesting that RNA editing may be another mechanism for tumourigenesis. several APOBEC-1-like proteins have been identified, including a family of APOBEC-1-related proteins with unknown function on chromosome 22. This review summarises the different types of RNA editing and discusses the current status of C to U apoB mRNA editing. This knowledge is very important in understanding the structure and function of these related proteins and their role in biology. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 13

页数：13

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