Curcumin-loaded dual pH- and thermo-responsive magnetic microcarriers based on pectin maleate for drug delivery

被引：63

作者：

Almeida, Elizangela A. M. S. ^{[1
]}

Bellettini, Ismael C. ^{[4
]}

Garcia, Francielle P.

Farinacio, Maroanne T. ^{[1
]}

Nakamura, Celso V. ^{[5
]}

Rubira, Adley F. ^{[1
]}

Martins, Alessandro F. ^{[2
,3
]}

Muniz, Edvani C. ^{[1
,2
]}

机构：

[1] Univ Estadual Maringa, GMPC, Dept Quim, BR-87020900 Maringa, Parana, Brazil

[2] Univ Tecnol Fed Parana UTFPR, Programa Posgrad Ciencia & Engn Mat PPGCEM, BR-86036370 Londrina, PR, Brazil

[3] Univ Tecnol Fed Parana UTFPR, Programa Posgrad Engn Ambiental PPGEA, BR-86812460 Apucarana, PR, Brazil

[4] Univ Fed Santa Catarina, Dept Quim, BR-89065300 Blumenau, SC, Brazil

[5] Univ Estadual Maringa, Dept Ciencias Basicas Saude, Lab Microbiol Aplicada Prod Nat & Sintet, BR-87020900 Maringa, Parana, Brazil

来源：

CARBOHYDRATE POLYMERS | 2017年 / 171卷

关键词：

Pectin; Magnetite; Poly(N-isopropyl acrylamide); Curcumin; Release; LIPOSOMAL CURCUMIN; IN-VITRO; RELEASE; NANOPARTICLES; CHITOSAN; CANCER; MICROSPHERES; HYPERTHERMIA; CELLS; COPOLYMER;

D O I：

10.1016/j.carbpol.2017.05.034

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Magnetic microgels with pH- and thermo-responsive properties were developed from the pectin maleate, N-isopropyl acrylamide, and Fe3O4 nanoparticles. The hybrid materials were characterized by infrared spectroscopy, scanning electron microscope coupled with X-ray energy dispersive spectroscopy, wide angle X-ray scattering, Zeta potential, and magnetization hysteresis measurements. Curcumin (CUR) was loaded into the microgels, and release assays were carried out in simulated environments (SGF and SIF) at different conditions of temperature (25 or 37 degrees C).A slow and sustainability CUR release was achieved under external magnetic field influence. Loaded CUR displayed stability, bioavailability and greater solubility regarding free CUR. Besides, the cytotoxicity assays showed that magnetic microgels without CUR could suppress the Caco-2 cells growth. So, the pectin maleate, N-isopropyl acrylamide, and Fe3O4 could be tailored to elicit hybrid-based materials with satisfactory application in the medical arena. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：259 / 266

页数：8

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