TNF family ligands define niches for T cell memory

被引:66
作者
Sabbagh, Laurent [1 ]
Snell, Laura M. [1 ]
Watts, Tania H. [1 ]
机构
[1] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada
基金
加拿大健康研究院;
关键词
D O I
10.1016/j.it.2007.06.001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immunological memory is a critical feature of the adaptive immune system and the underlying principal behind vaccination. The mechanisms that maintain memory T cell survival between the initial and subsequent encounter with antigen remain incompletely defined. Although the cytokines IL-15 and IL-7 are important in memory T cell homeostasis, additional signals by way of TNFR family members are required for maximal maintenance of T cell memory. Here we propose a unifying model in which subsets of TNF family ligands distinguish the competitive niches for maintenance of CD4 versus CD8 T cell memory. Understanding the unique 'memory niches' defined by TNF family ligand expression will provide new insights into the mechanisms of memory T cell maintenance.
引用
收藏
页码:333 / 339
页数:7
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