Ischemia and apoptosis in an animal model of permanent infarct-related artery occlusion

被引：11

作者：

Abbate, Antonio

Morales, Celina

De Falco, Maria

Fedele, Valentina

Zoccai, Giuseppe G. L. Biondi

Santini, Daniele

Palleiro, Jimena

Vasaturo, Fortunata

Scarpa, Susanna

Liuzzo, Giovanna

Severino, Anna

Baldi, Feliciano

Crea, Filippo

Biasucci, Luigi M.

Vetrovec, George W.

Gelpi, Ricardo J.

Baldi, Alfonso

机构：

[1] Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA USA

[2] Univ Buenos Aires, Inst Cardiovasc Physiopathol, Buenos Aires, DF, Argentina

[3] Univ Naples Federico 2, Dept Evolut & Comparat Biol, Naples, Italy

[4] Policlin San Donato, Dept Intervent Cardiol & Radiol, Milan, Italy

[5] Sect Oncol, Rome, Italy

[6] Univ Roma La Sapienza, Dept Expt Med & Pathol, Rome, Italy

[7] Catholic Univ, Inst Cardiol, Rome, Italy

[8] Univ Naples 2, Dept Biochem F Cedrangolo, Naples, Italy

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2007年 / 121卷 / 01期

关键词：

apoptosis; ischemia; remodelling; animal model; electron microscopy;

D O I：

10.1016/j.ijcard.2006.08.077

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Apoptosis is a pathologic feature of cardiomyocytes in acute myocardial infarction ( AMI) and heart failure. The temporal course of apoptosis in the peri-infarct area in the weeks following an AMI is still uncompletely defined. In order to study the time course of apoptosis after AMI, 16 rabbits underwent left coronary artery ligation and were sacrificed at 16, 26, 35, and 56 days after surgery. Increased apoptotic rate (AR) was observed at in the peri-infarct region than in remote myocardium (5.4% [2.5-9.6] vs 0.4% [ 0.1-0.9], respectively, P<0.001) and than in sham-operated cases ( 0.01% [ 0-0.02], P<b0.001). A gradual decrease of AR in the peri-infarct region was observed over time with a 90% reduction at 8 weeks after coronary ligation. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：109 / 111

页数：3

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