Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma during potent antiretroviral therapy

被引：62

作者：

Connick, E

Kane, MA

White, IE

Ryder, J

Campbell, TB

机构：

[1] Univ Colorado, Hlth Sci Ctr, Div Infect Dis, Denver, CO 80262 USA

[2] Univ Colorado, Hlth Sci Ctr, Dept Pathol, Denver, CO 80262 USA

[3] Univ Colorado, Ctr Canc, Denver, CO 80262 USA

[4] Denver Vet Affairs Med Ctr, Med Oncol Sect, Denver, CO USA

来源：

CLINICAL INFECTIOUS DISEASES | 2004年 / 39卷 / 12期

关键词：

D O I：

10.1086/426078

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rapidly progressive Kaposi sarcoma (KS) lesions with lymphadenopathy and tissue swelling occurred in a patient during antiretroviral treatment, despite an increased CD4(+) lymphocyte count and decreased HIV-1 level and KS-associated herpesvirus replication, suggesting immune reconstitution inflammatory syndrome. Inflammation resolved coincident with decreases in the CD4(+) lymphocyte count during paclitaxel treatment, whereas KS cleared only after prolonged antiretroviral therapy and chemotherapy.

引用

收藏

页码：1852 / 1855

页数：4

相关论文

共 12 条

[1] Regression of AIDS-related Kaposi's sarcoma following antiretroviral therapy with protease inhibitors: Biological correlates of clinical outcome [J].

Cattelan, AM ;

Calabro, ML ;

Aversa, SML ;

Zanchetta, M ;

Meneghetti, F ;

De Rossi, A ;

Chieco-Bianchi, L .

EUROPEAN JOURNAL OF CANCER, 1999, 35 (13) :1809-1815

[2] TAT PROTEIN OF HIV-1 STIMULATES GROWTH OF CELLS DERIVED FROM KAPOSIS-SARCOMA LESIONS OF AIDS PATIENTS [J].

ENSOLI, B ;

BARILLARI, G ;

SALAHUDDIN, SZ ;

GALLO, RC ;

WONGSTAAL, F .

NATURE, 1990, 345 (6270) :84-86

[3] Prospective study of the effects of antiretroviral therapy on Kaposi sarcoma-associated herpesvirus infection in patients with and without Kaposi sarcoma [J].

Gill, J ;

Bourboulia, D ;

Wilkinson, J ;

Hayes, P ;

Cope, A ;

Marcelin, AG ;

Calvez, V ;

Gotch, F ;

Boshoff, C ;

Gazzard, B .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2002, 31 (04) :384-390

[4] Survival of European patients with Kaposi's sarcoma as AIDS-defining condition during the first decade of AIDS [J].

Hermans, P ;

Lundgren, J ;

Sommereijns, B ;

Katlama, C ;

Chiesi, A ;

Goebel, FD ;

GonzalesLahoz, J ;

Proenza, R ;

Barton, SE ;

Pedersen, C ;

Clumeck, N .

AIDS, 1997, 11 (04) :525-531

[5] Immune reconstitution in HIV-infected patients [J].

Hirsch, HH ;

Kaufmann, G ;

Sendi, P ;

Battegay, M .

CLINICAL INFECTIOUS DISEASES, 2004, 38 (08) :1159-1166

[6]

Jones JL, 1999, J ACQ IMMUN DEF SYND, V21, pS11

[7] Clinical and biological impact of antiretroviral therapy with protease inhibitors on HIV-related Kaposi's sarcoma [J].

Lebbé, C ;

Blum, L ;

Pellet, C ;

Blanchard, G ;

Vérola, O ;

Morel, P ;

Danne, O ;

Calvo, F .

AIDS, 1998, 12 (07) :F45-F49

[8] KAPOSIS SARCOMA-CELLS - LONG-TERM CULTURE WITH GROWTH-FACTOR FROM RETROVIRUS-INFECTED CD4+ T-CELLS [J].

NAKAMURA, S ;

SALAHUDDIN, SZ ;

BIBERFELD, P ;

ENSOLI, B ;

MARKHAM, PD ;

WONGSTAAL, F ;

GALLO, RC .

SCIENCE, 1988, 242 (4877) :426-430

[9] Isolated intraparotid Kaposi sarcoma in human immunodeficiency virus type 1 infection [J].

Rizos, E ;

Drosos, AA ;

Ioannidis, JPA .

MAYO CLINIC PROCEEDINGS, 2003, 78 (12) :1561-1563

[10] Human immunodeficiency virus replication in a primary effusion lymphoma cell line stimulates lytic-phase replication of Kaposi's sarcoma-associated herpesvirus [J].

Varthakavi, V ;

Browning, PJ ;

Spearman, P .

JOURNAL OF VIROLOGY, 1999, 73 (12) :10329-10338