Antifungal chalcones from Maclura tinctoria

被引：119

作者：

ElSohly, HN

Joshi, AS

Nimrod, AC

Walker, LA

Clark, AM

机构：

[1] Univ Mississippi, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA

[2] Univ Mississippi, Dept Pharmacol, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Thad Cochran Res Ctr, Dept Pharmacognosy, University, MS 38677 USA

来源：

PLANTA MEDICA | 2001年 / 67卷 / 01期

关键词：

D O I：

10.1055/s-2001-10621

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Five prenylated flavonoids, including one new natural product, were isolated from an ethanol extract of the leaves of Maclura tinctoria (L.) Gaud. The new compound has been characterized as 2'4'4,2 "-tetrahydroxy-3'-[3"-methylbut-3 "-enyl]-chalcone (1). The known compounds were identified as 2'4'4-trihydroxy-3'-[3"-methylbut-3"-enyl]chalone (isobavachalcone) (2), 4,2'-dihydroxy-2 "-[1-hydroxy-1-methylethyl]-2"3 "-dihydrofurano[4",5":3'4]chalcone (bakuchalcone) (3), 4,4'5"-trihydroxy-6",6"-dimethyldihydropyrano[2",3":5',6"]chalcone (bavachromanol) (4), and 5,7,3:4'-tetrahydroxy-6,8-diprenylisoflavone (6,8-diprenylorobol) (5). All the isolated compounds were evaluated against the AIDS-related opportunistic fungal pathogens, Candida albicans and Cryptococcus neoformans. Compound 2 was active against both yeasts.

引用

页码：87 / 89

页数：3

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