Pulling the calcium trigger

被引：22

作者：

Sykes, BD ^{[1
]}

机构：

[1] Univ Alberta, Dept Biochem, CIHR Grp Prot Struct & Funct, Edmonton, AB T6G 2H7, Canada

来源：

NATURE STRUCTURAL BIOLOGY | 2003年 / 10卷 / 08期

关键词：

D O I：

10.1038/nsb0803-588

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of the calcium-bound core of human cardiac troponin reveals distinct subdomains connected by flexible linkers, implying that domain reorientation motions within the complex trigger muscle contraction.

引用

页码：588 / 589

页数：2

共 24 条

[1] Regulation of striated muscle contraction: a discussion [J].

Chalovich, JM .

JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 2002, 23 (04) :353-361

[2] Solution structure of calcium-saturated cardiac troponin C bound to cardiac troponin I [J].

Dvoretsky, A ;

Abusamhadneh, EM ;

Howarth, JW ;

Rosevear, PR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (41) :38565-38570

[3]

Ebashi S, 1974, Essays Biochem, V10, P1

[4] In situ orientations of protein domains: Troponin C in skeletal muscle fibers [J].

Ferguson, RE ;

Sun, YB ;

Mercier, P ;

Brack, AS ;

Sykes, BD ;

Corrie, JET ;

Trentham, DR ;

Irving, M .

MOLECULAR CELL, 2003, 11 (04) :865-874

[5] STRUCTURES OF THE TROPONIN-C REGULATORY DOMAINS IN THE APO AND CALCIUM-SATURATED STATES [J].

GAGNE, SM ;

TSUDA, S ;

LI, MX ;

SMILLIE, LB ;

SYKES, BD .

NATURE STRUCTURAL BIOLOGY, 1995, 2 (09) :784-789

[6]

HEELEY DH, 1987, J BIOL CHEM, V262, P9971

[7] Small-angle neutron scattering with contrast variation reveals spatial relationships between the three subunits in the ternary cardiac troponin complex and the effects of troponin I phosphorylation [J].

Heller, WT ;

Finley, NL ;

Dong, WJ ;

Timmins, P ;

Cheung, HC ;

Rosevear, PR ;

Trewhella, J .

BIOCHEMISTRY, 2003, 42 (25) :7790-7800

[8] The solution structure of a cardiac troponin C-troponin I-troponin T complex shows a somewhat compact troponin c interacting with an extended troponin I-Troponin T component [J].

Heller, WT ;

Abusamhadneh, E ;

Finley, N ;

Rosevear, PR ;

Trewhella, J .

BIOCHEMISTRY, 2002, 41 (52) :15654-15663

[9] Plasticity in skeletal cardiac, and smooth muscle -: Invited review:: Pathophysiology of cardiac muscle contraction and relaxation as a result of alterations in thin filament regulation [J].

Hernandez, OM ;

Housmans, PR ;

Potter, JD .

JOURNAL OF APPLIED PHYSIOLOGY, 2001, 90 (03) :1125-1136

[10] STRUCTURE OF THE CALCIUM REGULATORY MUSCLE PROTEIN TROPONIN-C AT 2.8-A RESOLUTION [J].

HERZBERG, O ;

JAMES, MNG .

NATURE, 1985, 313 (6004) :653-659

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