Prolonged survival of murine cardiac allografts by treatment with the 4-amino analog of tetrahydrobiopterin

被引:4
作者
Brandacher, G
Zou, Y
Obrist, P
Steurer, W
Werner-Felmayer, G
Margreiter, R
Werner, ER
机构
[1] Univ Innsbruck Hosp, Dept Transplant Surg, A-6020 Innsbruck, Austria
[2] Univ Innsbruck, Inst Pathol, A-6020 Innsbruck, Austria
[3] Univ Innsbruck, Inst Med Chem & Biochem, A-6020 Innsbruck, Austria
关键词
D O I
10.1016/S0041-1345(00)02117-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:516 / 517
页数:2
相关论文
共 12 条
[1]  
Billingham M E, 1990, J Heart Transplant, V9, P587
[2]  
CATTELL V, 1994, TRANSPLANTATION, V58, P1399
[3]   Requirement for type 2 NO synthase for IL-12 signaling in innate immunity [J].
Diefenbach, A ;
Schindler, H ;
Röllinghoff, M ;
Yokoyama, WM ;
Bogdan, C .
SCIENCE, 1999, 284 (5416) :951-955
[4]   Type 1 interferon (IFNα/β) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite [J].
Diefenbach, A ;
Schindler, H ;
Donhauser, N ;
Lorenz, E ;
Laskay, T ;
MacMicking, J ;
Röllinghoff, M ;
Gresser, I ;
Bogdan, C .
IMMUNITY, 1998, 8 (01) :77-87
[5]   Tetrahydrobiopterin binding to macrophage inducible nitric oxide synthase: Heme spin shift and dimer stabilization by the potent pterin antagonist 4-amino-tetrahydrobiopterin [J].
Mayer, B ;
Wu, CQ ;
Gorren, ACF ;
Pfeiffer, S ;
Schmidt, K ;
Clark, P ;
Stuehr, DJ ;
Werner, ER .
BIOCHEMISTRY, 1997, 36 (27) :8422-8427
[6]  
MONCADA S, 1991, PHARMACOL REV, V43, P109
[7]   Preferential inhibition of inducible nitric oxide synthase in intact cells by the 4-amino analogue of tetrahydrobiopterin [J].
Schmidt, K ;
Werner-Felmayer, G ;
Mayer, B ;
Werner, ER .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 259 (1-2) :25-31
[8]   Apoptosis and increased expression of inducible nitric oxide synthase in human allograft rejection [J].
Szabolcs, MJ ;
Ravalli, S ;
Minanov, O ;
Sciacca, RR ;
Michler, RE ;
Cannon, PJ .
TRANSPLANTATION, 1998, 65 (06) :804-812
[9]   Identification of the 4-amino analogue of tetrahydrobiopterin as a dihydropteridine reductase inhibitor and a potent pteridine antagonist of rat neuronal nitric oxide synthase [J].
Werner, ER ;
Pitters, E ;
Schmidt, K ;
Wachter, H ;
WernerFelmayer, G ;
Mayer, B .
BIOCHEMICAL JOURNAL, 1996, 320 :193-196
[10]   Inhibition of inducible nitric oxide synthase attenuates established acute cardiac allograft rejection [J].
Worrall, NK ;
Misko, TP ;
Sullivan, PM ;
Hui, JJ ;
Ferguson, TB .
ANNALS OF THORACIC SURGERY, 1996, 62 (02) :378-385