The influence of advanced glycation endproducts (AGE) on the expression of human endothelial adhesion molecules

被引：44

作者：

Kunt, T

Forst, T

Harzer, O

Buchert, G

Pfützner, A

Löbig, M

Zschäbitz, A

Stofft, E

Engelbach, M

Beyer, J

机构：

[1] Univ Mainz, Dept Internal Med & Endocrinol, D-55131 Mainz, Germany

[2] Univ Mainz, Inst Anat, D-55131 Mainz, Germany

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 1998年 / 106卷 / 03期

关键词：

advanced glycation endproducts; vascular cell adhesion molecule-1; intercellular adhesion molecule-1; E-selectin;

D O I：

10.1055/s-0029-1211974

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Advanced glycation endproducts (AGEs) possibly play a dominant role in the pathogenesis of macrovascular disease in diabetes. Recent studies could demonstrate that glycated albumin (AGE-BSA) was able to stimulate vascular cell adhesion molecule-1 (VCAM.1) on endothelial cells. The aim of this study was to find out if AGE-BSA was not only able to enhance the expression of vascular cell adhesion molecule-1, but also of intercellular adhesion molecule-1 (ICAM-1) and E-Selectin on human endothelial cells. Stimulation of endothelial cells with AGE-BSA for six hours predominantly increased the expression of VCAM-1, but ICAM-1 and E-Selectin were also upregulated as shown by immunoilluminometric assay (ILMA).

引用

页码：183 / 188

页数：6

共 31 条

[1] FORMATION OF IMMUNOCHEMICAL ADVANCED GLYCOSYLATION END-PRODUCTS PRECEDES AND CORRELATES WITH EARLY MANIFESTATIONS OF RENAL AND RETINAL DISEASE IN DIABETES [J].