Insulin analogues:: impact of cell model characteristics on results and conclusions regarding mitogenic properties

被引:14
作者
Kellerer, M [1 ]
Häring, HU [1 ]
机构
[1] Univ Tubingen, Med Klin & Poliklin, Abt Innere 4, D-72076 Tubingen, Germany
关键词
D O I
10.1055/s-2001-11022
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:63 / 64
页数:2
相关论文
共 7 条
[1]   Growth promoting and metabolic activity of the human insulin analogue [Gly(A21),Arg(B31),Arg(B32)]insulin (HOE 901) in muscle cells [J].
Bahr, M ;
Kolter, T ;
Seipke, G ;
Eckel, J .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 320 (2-3) :259-265
[2]   The long acting human insulin analog HOE 901:: Characteristics of insulin signalling in comparison to Asp(B10) and regular insulin [J].
Berti, L ;
Kellerer, M ;
Bossenmaier, B ;
Seffer, E ;
Seipke, G ;
Häring, HU .
HORMONE AND METABOLIC RESEARCH, 1998, 30 (03) :123-129
[3]   THE BIOACTIVITY OF INSULIN ANALOGS FROM INVITRO RECEPTOR-BINDING TO INVIVO GLUCOSE-UPTAKE [J].
DREJER, K .
DIABETES-METABOLISM REVIEWS, 1992, 8 (03) :259-285
[4]  
Hansen BF, 1996, BIOCHEM J, V315, P271
[5]   Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use [J].
Kurtzhals, P ;
Schäffer, L ;
Sorensen, A ;
Kristensen, C ;
Jonassen, I ;
Schmid, C ;
Trüb, T .
DIABETES, 2000, 49 (06) :999-1005
[6]   Insulin receptor-deficient cells as a new tool for dissecting complex interplay in insulin and insulin-like growth factors [J].
Lamothe, B ;
Baudry, A ;
Christoffersen, CT ;
De Meyts, P ;
Jami, J ;
Bucchini, D ;
Joshi, RL .
FEBS LETTERS, 1998, 426 (03) :381-385
[7]   Modifications in the B10 and B26-30 regions of the B chain of human insulin alter affinity for the human IGF-I receptor more than for the insulin receptor [J].
Slieker, LJ ;
Brooke, GS ;
DiMarchi, RD ;
Flora, DB ;
Green, LK ;
Hoffmann, JA ;
Long, HB ;
Fan, L ;
Shields, JE ;
Sundell, KL ;
Surface, PL ;
Chance, RE .
DIABETOLOGIA, 1997, 40 (Suppl 2) :S54-S61