Lysophosphatidylcholine upregulates CD40 ligand expression in newly activated human CD4+ T cells

被引：30

作者：

Sakata-Kaneko, S ^{[1
]}

Wakatsuki, Y ^{[1
]}

Usui, T ^{[1
]}

Matsunaga, Y ^{[1
]}

Itoh, T ^{[1
]}

Nishi, E ^{[1
]}

Kume, N ^{[1
]}

Kita, T ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Clin Bioregulatory Sci, Sakyo Ku, Kyoto 6068507, Japan

来源：

FEBS LETTERS | 1998年 / 433卷 / 1-2期

基金：

日本学术振兴会;

关键词：

lysophosphatidylcholine; CD28-CD80; costimulation; CD4 T cell; CD40; ligand; atherosclerosis;

D O I：

10.1016/S0014-5793(98)00898-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lysophosphatidylcholine (lyso-PC) accumulates in tissues undergoing inflammation and atherosclerosis, where an infiltration of T cells is also seen. We found that lyso-PC increased IFN-gamma production and CD40L expression in CD4+ T cells stimulated with anti-CD3 Ab and recombinant CD80 molecules, whereas lyso-PC did not affect IL-2 and IL-4 production, These results suggest that lyso-PC, in combination with other stimuli, may regulate CD4+ T cell functions to propagate local inflammatory reactions and also imply a novel role played by a modified lipid in the selection of Th1/Th2 immune response as well as in the T cell mediated pathogenesis in atherosclerosis. (C) 1998 Federation of European Biochemical Societies.

引用

页码：161 / 165

页数：5

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