α-glucosidase inhibitory action of natural acylated anthocyanins.: 1.: Survey of natural pigments with potent inhibitory activity

被引：315

作者：

Matsui, T ^{[1
]}

Ueda, T

Oki, T

Sugita, K

Terahara, N

Matsumoto, K

机构：

[1] Kyushu Univ, Grad Sch, Fac Agr,Div Bioresource & Bioenvironm Sci, Dept Biosci & Biotechnol,Higashi Ku, Fukuoka 8128581, Japan

[2] Miyazaki JA Food Res & Dev Inc, Miyazaki 8800943, Japan

[3] Minami Kyushu Univ, Coll Hort, Dept Food Sci & Technol, Miyazaki 8840003, Japan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2001年 / 49卷 / 04期

关键词：

alpha-glucosidase; anthocyanins; inhibition; non-insulin-dependent diabetes mellitus;

D O I：

10.1021/jf001251u

中图分类号：

S [农业科学];

学科分类号：

09 [农学];

摘要：

alpha -Glucosidase (ACH) inhibitory study by natural anthocyanin extracts was done. As the result of a free AGH assay system, 12 anthocyanin extracts were found to have a potent AGH inhibitory activity; in particular, Pharbitis nil (SOA) extract showed the strongest maltase inhibitory activity, with an IC50 value of 0.35 mg/mL, as great as that of Ipomoea batatas (YGM) extract (IC50 = 0.36 mg/mL). Interestingly, neither extract inhibited the sucrase activity at all. For the immobilized assay system, which may reflect the pharmacokinetics of AGH at the small intestine, SOA and YGM extracts gave more potent maltase inhibitory activities than those of the free AGH assay, with IC50 values of 0.17 and 0.26 mg/mL, respectively. Both extracts also inhibited alpha -amylase action, indicating that anthocyanins would have a potential function to suppress the increase in postprandial glucose level from starch.

引用

页码：1948 / 1951

页数：4

共 25 条

[1]

[Anonymous], HORUMON TO RINSHO

[2]

[Anonymous], CHOOSE USE DRUGS DIA

[3]

GOTO Y, 1989, YAKURI TO CHIRYO, V17, P387

[4]

THE INHIBITION OF ALPHA-AMYLASE BY TEA POLYPHENOLS [J].

HARA, Y ;

HONDA, M .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1990, 54 (08) :1939-1945

[5]

HAURI HP, 1982, J BIOL CHEM, V257, P4522

[6]

Matsui T, 1999, Z NATURFORSCH C, V54, P259

[7]

In vitro survey of alpha-glucosidase inhibitory food components [J].

Matsui, T ;

Yoshimoto, C ;

Osajima, K ;

Oki, T ;

Osajima, Y .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1996, 60 (12) :2019-2022

[8]

REDUCTION OF BLOOD-GLUCOSE LEVELS BY TEA CATECHIN [J].

MATSUMOTO, N ;

ISHIGAKI, F ;

ISHIGAKI, A ;

IWASHINA, H ;

HARA, Y .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1993, 57 (04) :525-527

[9]

MATSUMOTO N, 1992, FOOD IND, V34, P26

[10]

Matsuura T., 1997, Nippon Eiyo Shokuryo Gakkaishi = Journal of the Japanese Society of Nutrition and Food Science, V50, P363

← 1 2 3 →