Cyclooxygenase-2 is overexpressed in serrated adenoma of the colorectum

被引：19

作者：

Arao, J

Sano, Y

Fujii, T

Kato, S

Fu, KI

Yoshino, T

Ochiai, A

Fujimori, T

Yoshida, S

机构：

[1] Natl Canc Ctr Hosp E, Div Digest Endoscopy & Gastrointestinal Oncol, Chiba 2778577, Japan

[2] Natl Canc Ctr Hosp E, Div Pathol, Chiba 2778577, Japan

[3] Dokkyo Univ, Sch Med, Dept Pathol 2, Mibu, Tochigi, Japan

[4] Natl Canc Ctr Hosp, Div Digest Endoscopy, Tokyo, Japan

来源：

DISEASES OF THE COLON & RECTUM | 2001年 / 44卷 / 09期

关键词：

cyclooxygenase-2; hyperplastic polyp; serrated adenoma; immunohistochemistry;

D O I：

10.1007/BF02234791

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

PURPOSE: The aim of this study was to clarify whether cyclooxygenase-2 and cyclooxygenase-1 is expressed in hyperplastic polyps and serrated adenomas. METHODS: Forty-nine serrated adenomas and 25 hyperplastic polyps were immunostained using anticyclooxygenase-2 and anticyclooxyenase-1 antibodies. Cyclooxygenase-2 and cyclooxygenase-1 expression was investigated in all specimens. RESULTS: Cyclooxygenase-2 was expressed in dysplastic glands in the majority of serrated adenomas. Thirty-five of 49 (71.4 percent) serrated adenomas exhibited moderate to intense cyclooxygenase-2 immunoreactivity, and 8 of 25 hyperplastic polyps (32 percent) showed weak to moderate cyclooxygenase-2 immunoreactivity. Cyclooxygenase-1 immunoreactivity was very weak in all the hyperplastic polyps and serrated adenomas. CONCLUSIONS: These results suggest that cyclooxygenase-2 is overexpressed in serrated adenoma of the colorectum. Cyclooxygenase-2 inhibitors will reduce the incidence of serrated adenomas.

引用

页码：1319 / 1323

页数：5

共 27 条

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